We modeled the abundance of each mRNA as a function of the combinatorial effect of RBPs that bind to that mRNA (see Experimental Procedures), with the mRNA-RBP interactions derived from a previously reported “high-confidence” stability network (Ray et al., 2013). Following previously ...
of growth factors such as insulin-like growth factor 1 (IGF1) through cleavage of insulin like growth factor binding protein 3 and Transforming Growth ... Singh PWilliams SAShah MHLectka TPritchard GJIsaacs JTDenmeade SR - 《Proteins Structure Function & Genetics》 被引量: 0发表: 2008年 加...
5a). KatE (HPII) is one of the two catalases in E. coli, the expression of which depends on general stress sigma factor σS 26. The direct proximity between katE and cedA promoters suggests the two genes may share a common function. Indeed, the expression of katE and cedA is induced ...
MRNA which includes the base array which is shown in the manner, and general formula (i) below, measures gene transcription function due toPROBLEM TO BE SOLVED: To provide a method for selectively measuring the cDNA amplified from a foreign gene of a very small quantity even in the case ...
in Figure 1d, each of the mo ulation schemes escribe above yiel s a typical curve for b as a function of the mean mRNA level 〈n〉. These curves are istinct from each other; thus, measuring b(〈n〉) experimen- tally woul in principle allow us to iscriminate among the ifferen...
Research has shown that the significance of these three residues can vary across species, with metazoan and yeast systems sometimes exhibiting different behaviors [37,38]. Exploring the function of these other important Pol II CTD residues provides numerous areas for future study. Figure 1. ...
Cooperating factors can influence the specificity and affinity of transcription factors binding and can significantly alter the function of a bound transcription factor, greatly influencing gene regulation. For example, more than 3700 OCT4, 4500 SOX2, and 10,000 Nanog-binding sites have been...
Furthermore, we demonstrate that Sam68 can function alone as well as synergize with Rev-MS2 and/or Rex-MS2 chimeric proteins on expression mediated by the corresponding RRE-MS2 fusion RNA element. Additionally, dominant negative mutants of Sam68 also repressed the synergistic activation of Sam68 ...
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In the current review we will summarize the general principals of miRNA biogenesis and function. We will discuss the various mechanisms that contribute to the regulation of miRNA expression, stability, and activity with a specific focus on the role of miRNAs in the nervous system. GENERAL ...