This chapter will review the function of BDNF and its relationship to the Val66Met marker, highlighting important gene × environment interactions that may explain existing discrepancies in the literature.doi:10.1002/9781119057840.ch38Lauren E. Salminen...
Gene x environment interactions in the prediction of response to antidepressant treatmentKlengelT.BinderE.B.ingentaconnectInternational Journal of NeuropsychopharmacologyT. Klengel and E. B. Binder, "Gene x environment interactions in the prediction of response to antidepressant treatment," International ...
Resultsdependonscale–oftenremoveGxE(andother“interactions”–e.g.epistasis)bychangeinscaleOftentrytochooseunitssomodelisadditive/linearandsimple.“Simplicityistruth”(?)“Environment”•Micro-environment(unmeasured,random)“E”and“C”intwinmodels•Macro-environment(measured,?”fixed”)SES,lifeevents,...
"Our findings explain mechanistically the observed genexenvironment interaction in mesothelioma that occurs in carriers of germline BAP1 mutations exposed to asbestos," said Novelli, a postdoctoral researcher and first author of the paper. "This publication is the result of amazing teamwork and collabora...
Abstract Genotype × environment interactions (GxE) have long been recognized as a key mechanism underlying human phenotypic variation. Technological developments over the past 15 years have dramatically expanded our appreciation of the role of GxE in both gene regulation and complex traits. The ri...
Studies of gene–environment (G×E) interactions can be useful for investigating biological pathways, and can reveal genes that act only in particular environments or exposures that are hazardous only to genetically susceptible individuals. Such knowledge can be used for setting environmental safety stan...
Gene-environment interactions are considered in Chap. 10, which focuses on a 2×2×2 table. The expressions of odds ratios for the genetic effect, the environmental factor effect, and the gene-environment interaction are given. More general cases for gene and environmental factors are briefly dis...
Gene X Environment Interactions in Primates: An Evolutonary Perspective 来自 Semantic Scholar 喜欢 0 阅读量: 2 作者: S Suomi 年份: 2010 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Semantic Scholar 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供...
A partial least-square approach for modeling gene–gene and gene–environment interactions when multiple markers are genotyped. Genet Epidemiol Off Publ Int Genet Epidemiol Soc. 2009;33(1):6–15. CAS Google Scholar Li J, Tang R, Biernacka JM, De Andrade M. Identification of gene–gene ...
Uncovering the interaction between genomes and the environment is a principal challenge of modern genomics and preventive medicine. While theoretical models are well defined, little is known of the G × E interactions in humans. We used an integrat