MRTX849 exhibits a 24-h half-life and wider tissue distribution. In the phase I/II KRYSTAL-1 study on 116 cancer patients carrying KRAS G12C mutations, 42.9% demonstrated confirmed objective responses, with a median duration of 8.5 months, progression-free survival of 6.5 months...
Although more than half of all genes generate transcripts that differ in 3′UTR length, current analysis pipelines only quantify the amount but not the length of mRNA transcripts. 3′UTR length is determined by 3′ end cleavage sites (CS). We map CS
Capital Formation | Shaping Innovation Panelists will discuss the life sciences capital markets environment with particular emphasis on private and public fundraising for GCT companies. What trends do panelists observe that will impact the availability and cost of capital for GCT? Are there novel fundr...
Blessed Wormlings Hivewyrm Broodmind Psychic Disciplines The Genestealer Patriarch and Magus are potent psykers, able to use their formidable powers to bend others to their will. This mental dominance not only ensures that the gestalt consciousness of the cult's masses serves as one, but can al...
the RBCM biomimetic nanocomposites were found to have excellent and unique properties such as a long plasma half-life and excellentBBBpenetration. During subsequent testing of the GBM mouse model, significant early and late apoptoses of tumor cells were observed, and the mice showed few systemicadv...
16 Fatty acids are shown to prompt settlement and metamorphosis of tube worm Phragmatopoma califomica larvae.17 Settlement-inducing protein complex (SIPC) can induce larval settlement of the barnacle, Balanus amphitrite.18 However, this process is not well explained at the molecular level. One of...
[Walsh, 1995;Lynch et al., 2001]. Duplicate genes are lost more slowly in multicellular than in unicellular organisms. The half-life of duplicate genes increases with thegenome size[Lynch and Conery, 2003]. Dying duplicates are more similar to each other than preserved duplicates [Marotta et...
Worm gene offers clues to longer life in humans, study findsNicholas Wade
Mainly known as a transcription factor patterning the rostral brain and governing its histogenesis, FOXG1 has been also detected outside the nucleus; however, biological meaning of that has been only partially clarified. Prompted by FOXG1 expression in c
The bacterial ADHs of the TADH family stem from a number of species, representing both Gram-negative and Gram-positive forms. However, apart from the bacterial and yeast forms, the TADH family also has two members from the wormCaenorhabditis elegans. ...