Genes come in multiple forms or versions. Each of these forms is called an allele. For example, the gene responsible for the hair color trait has many alleles: an allele for brown hair, an allele for blonde hair, an allele for red hair, and so on. Function Genes govern the traits of ...
To assess the impact of rarecis-variants (MAF < 0.05) on the homoeolog expression levels, we investigated the relationship between the expression ranks of each homoeolog in the population, ordered from lowest to highest expression levels across wheat accessions, and the rare allele load in th...
Results showed that the effects of the top-associatedcis-eQTLs were highly correlated between all the brain regions in GTEx after correcting for estimation errors, with a meanr^bof 0.94 (s.e. = 0.004; Fig.1). These estimates are higher than the Spearman correlation estimates reported in ...
After adjustment for cardiovascular risk factors, analysis of the additive and dominant models involving rs36071027 also revealed that T allele carriers had a significantly higher risk for CAD than C allele carriers (additive model: OR 1.56, 95% CI 1.10–2.22,P= 0.013; dominant model: OR ...
eradicate, then they can create a gene drive specific to that population. The drive would spread only to individuals carrying that specific allele; it wouldn't work in individuals without that specific allele. The researchers described this method in a 2019 study published in the journalScientific...
Male mice in these 6 lines were first bred to E2a-Cre female (JAX 003724), heterozygous offspring carrying post-Cre (null) allele were used for further crossing. We bred heterozygous KO mice for 52 genes (Table S1) to Q140 KI mice to generate offspring with 4 different genotypes. For ...
The second class of approaches is that of site frequency spectra (SFS), which use histograms of allele frequencies to estimate the magnitude of fitness effects in pre-defined sites in comparison to a neutral class. In doing so, this approach distinguishes sites subject to selection, allowing ...
When looking into the possible molecular assays in distinguishing the different alleles, we found that it is actually possible to design allele-specific primers to detect the expression level of duplication pairs. Conclusion We improved the tag-to-gene mapping strategy by combining information from ...
the generation of variants that express different alleles of specific genes. It has been shown that alleles derived from different organisms can drastically improve microbial production titers11,39,95,96and combining allele and GEM shuffling would allow to tackle this extra layer of metabolic ...
(p = 1.37 × 10−25, score test). The numbers in brackets denote the number of carriers of at least one alternative allele. Center lines denote the medians. The lower and upper hinges indicate 25th and 75th percentiles. Whiskers extend to the largest/lowest values no further ...