SCID-X1 The genotoxic events observed in early SCID-X1 clinical trials led to worldwide recognition that genotoxicity is a major obstacle for retroviral HSC gene therapy. In two trials with gammaretroviral vectors, 5 of 20 enrolled patients developed T cell leukemia [12,50]. In these patients,...
Introduction Coffee is consumed worldwide, and consumption rates in Norway (9.7 kg per capita) are surpassed only by Finland (12.3 kg per capita) [1]. On average, Norwegian women consume 454 grams of brewed coffee per day [2]. There has been a growing interest in studying the associations...