Knowing you have a genetic mutation that puts you at risk of ovarian cancer can be life-saving. But with complex decisions awaiting anyone who has a disease variant, many people are choosing not to be tested.doi:10.1038/d41586-021-03720-yJyoti Madhusoodanan...
Thus, gene panel testing is now an option in the setting of genetic counseling and testing for cancer risk. This article describes the many gene panel testing options clinically available to assess inherited cancer susceptibility, the potential advantages and challenges associated with various types of...
Kurian, MD, MSc1 Purpose: We examined racial/ethnic differences in the usage and results of germ-line multiple-gene sequencing (MGS) panels to evaluate hereditary cancer risk. Methods: We collected genetic testing results and clinical information from 1,483 patients who underwent MGS at Stanford ...
Genetic testing for breast cancer gene (BRCA) mutations is offered to women who have a risk ≥10% of carrying a mutation. The objectives of the ... CD Murphy,JM Lee,B Drohan,... - 《Cancer》 被引量: 228发表: 2010年 A single-nucleotide polymorphism in the RAD51 gene modifies breast...
inform public health strategies for targeted prevention. Gene– environment interaction studies may also help to discover novel genetic risk factors; for example, variants in NAT2 and GSTM1 may not have been identified as relevant genetic risk factors, if their association with bladder cancer risk ...
Genetic testing can determine whether a person carries a mutation within the BRCA1 gene that is known to increasecancer risk. Those who do may need more frequentcancerscreening than is recommended for people of average risk. They may also consider prophylactic surgery or chemoprevention to reduce ...
undergoinggenetic testingand having preventative mastectomies to reduce their risk of breast cancer if they are found to have the BRCA genetic mutation. This increased access to testing has resulted in greater detection of BRCA mutations and has undoubtedly led to life-saving preventative care for ...
If you have registered for alerts, you should use your registered email address as your username Citation tools Download this article to citation manager Mayor Susan. UK scientists recommend gene testing for inherited bowel cancer BMJ 2001; 323:10 BibTeX (win & mac)Download EndNote (tagged)Do...
The advent of gene panel testing is challenging the previous practice of using clinically defined cancer familysyndromes to inform single-gene genetic scre... ND Tu,JA Steen,I Winship,... - 《Familial Cancer》 被引量: 0发表: 2020年 Risk of colorectal cancer for people with a mutation in ...
Rogan, Canada Research Chair in Genome Bioinformatics, says that 16 to 20 per cent of women in southwestern Ontario, who have their BRCA genes tested for breast and/or ovarian cancer risk, carry disease-causing gene variants that are well-understood by clinicians and genetic counselors. If a p...