using nonsurgical technique to control artificial prosthesis osteolysis is an urgent and realistic task.Currently,the drug prevents osteolysis through inhibiting osteoclast bone resorption,responding to cytokines,and promoting bone formation.In addition,gene therapy and other treatments for osteolysis are ...
(PNP,EC 2.4.2.1) is an important enzyme which is applied in nucleoside medication and intermediate biosynthesis.In this paper,we aimed to obtain the PNP gene from cold-adapted marine bacterium Pseudoalteromonas sp.XM2107 and study the characteristics of enzyme for applying in nucleoside medication ...
To investigate the role of inflammation in MDD, several studies available so far have measured the mRNA levels of genes involved in inflammation in the peripheral blood and postmortem brain tissues of patients with MDD (see Table1). For example, the study conducted by Rizavi et al. in 201623...
Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of MDD Symptoms View LargeDownload Figure. Screening, Enrollment, Randomization, and Outcomes Among Individuals in the Study of Antidepressant Pharmacogenomics View LargeDownload PHQ-9 indicates Patient Health ...
Aim:The aim of this study was to replicate a previously reported association between drug resistance in epilepsy patients and the 24C>T variant of theABCC2gene that codes for the drug efflux transporter MRP2.Patients & methods:We genotyped 381 Caucasian epileptic patients (337 drug resistant and ...
2)The control group was defined as patients who had received one antihypertensive drug for at least 1 year, and who had never received two or more antihypertensive drugs. To exclude patients who discontinued a medication shortly after initiation, we selected patients who had received any antihyperte...
Thrombopoietin (TPO) is likely to he a potent, specific and reliable medication in the treatment of thrombocytopenia. A TPO-highly-expressed plasmid pcDNA3-TPO was constructed and a primary study was made on the expression of TPO cDNAin vitro and gene transfer study for thrombocytopeniain vivo....
Another advantage is its viral capability to carry a large load of transgenes, such as a pro-drug-activating gene thymidine kinase enzyme that enhances tumor lysis when ganciclovir medication is subsequently administered intravenously (suicide gene) [45]; therapeutic immunomodulatory transgenes that ...
seizure burden, medication load, and psychosocial challenges that medically-intractable patients often face. Notably, when split into short vs. long duration groups, patients with a longer disease duration also presented with topological regularization primarily in temporo-parietal cortices. This is in ...
as the Shope papilloma genome did not encode for arginase production. In a 1980 study that was not formally published, Dr. Martin Cline attempted to insert recombinant β-globin, a factor needed in the production of hemoglobin, into bone marrow cells of two patients with β-thalassemia.2The ...