Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation of the joints and may cause inflammation of other tissues in the body. It is mainly caused by combination of factors including
Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2, 364–371, https://doi.org/10.1038/ nri802 (2002). 14. Schottelius, A. J. et al. Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol 13, 193–222, https://doi.org /10.1111/j....
Although patients with rheumatoid arthritis (RA) typically exhibit symmetrical joint involvement, some patients develop alternative disease patterns in response to treatment, suggesting that different molecular mechanism may underlie disease progression depending on joint location. Here, we identify joint-specif...
Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has b...
Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients GeneJournal2016,Gene George N.Goulielmos, ...FrederiquePonchel 3.3Gene–Gene interactions Gene×Gene interaction(G×G) refers to the situation in which the effect of one genotype is conditional on ...
The corre- sponding 95% confidence intervals decreased 1.39 cM for RF IgM and 1.59 cM for age at onset. In addition, after incorporating anti-CCP, IgM RF, or age at onset, the stand- ar]]>Rheumatoid arthritis is a complex disease in which environmental factors interact with genetic ...
For all cancer patients, a clinical assessment of this diagnosis must include the simultaneous presence of new pleural effusion, upper extremity thrombosis, or the presence of lymphadenopathy at the clavicular/mediastinal locations.Due to improperly functioning osteoclasts, rheumatoid arthritis (RA) exhibits...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical, polyarticular inflammation of small joints. The pathogenesis of RA remains unclear, and it can affect multiple organ systems [210]. Autoimmune reactions and inflammation are the primary mechanisms involved, encompassing variou...
Elucidation of the mutation will improve our understanding of the genetic control of osteoclast function and may indicate novel therapeutic paradigms in osteopetrosis, osteoporosis and rheumatoid arthritis where failed bone homeostasis is an instigating or exacerbating component of the disease process....
Prickett and Jain summarize advances in gene transfer and gene repair of the cystic fibrosis transmembrane regulator gene, and a new perspective on the gene therapy of rheumatoid arthritis and osteoarthritis is given by Evans, Ghivizzani, and Robbins. Looking forward, this information will be ...