TRANSCRIPTION factorsGENETIC regulationGENE expressionThe article discusses research being done on the effect of transcription factor binding to DNA regulatory sequences on spatio-temporal expression of genes, which references the study "Genome-wide protein-DNA binding dynamics suggest a molecular clutch ...
Bayesian sparse hidden components analysis for transcription regulation networks. Bioinformatics. 2006;22(6):739-746 20. Chen G, Jensen ST, Stoeckert CJ Jr. Clustering of genes into regulons using integrated modeling-COGRIM. Genome Biology. 2007;8(1):R4 21. Shi X et al. mAPC-GibbsOS: ...
Specific recognition ofcis-regulatory regions is essential for correct gene regulation in response to developmental and environmental signals. Such DNA sequences are recognized by transcription factors (TFs) that recruit the transcriptional machinery. Achievement of specific sequence recognition is not a tri...
In bioinformatics, binding of transcription regulatory factors to the cognate binding sites is usually described by sequence-specific binding energy, which... EA Kotelnikova,VJ Makeev,MS Gelfand - 《Gene》 被引量: 87发表: 2005年 On the evolution of gene regulation The regulation of a gene depe...
HIF-1伪 has also been shown to interact with several other transcription factors and function as a coactivator or corepressor. HIF-1 mediates adaptive responses to hypoxia that are systemic, such as increased erythropoiesis, as well as responses that are cell autonomous, such as regulation of the...
the activation level of each of the N objects is represented by a value in a given discrete set of values; the simplest case is the Boolean set {0, 1} where 0 indicates low concentration of signal transducers or no activation of gene and transcription factors, and 1 indicating the opposit...
DNA sequences where transcription factors can bind to drive gene regulation, usually represented as nucleotide patterns known as motifs. Eigenvector centrality A network centrality measure describing the importance of a node in the network based on the centrality of its neighbours. Enhancers Distal regu...
, altering the accessibility of chromosomal DNA to transcription factors and RNA polymerases. Other complexes directly influence the frequency at which RNA polymerases bind to promoters and initiate transcription. The complicated scenario makes it rather difficult describing the behavior of gene regulation....
Regulation of transcription is considered to be an interplay of tissue and developmental-specific transcription factors (TFs) and chromatin modifying factors acting on enhancer and promoter sequences to facilitate the assembly of the transcription machinery at gene promoters. With a growing number of lnc...
The weak, fine-tuned binding of ubiquitous transcription factors to the Il-2 enhancer contributes to its T cell-restricted activity. Nucleic Acids Res. 20, 2657–2665 (1992). Article CAS PubMed PubMed Central Google Scholar Jiang, J. & Levine, M. Binding affinities and cooperative ...