Regulation of Transcription in Eukaryotic Cells 2. Post-transcriptional regulation Gene expression can be regulated by post-transcriptional mRNA processing. In eukaryotes, transcribed mRNA undergoes splicing and other modifications that protect the ends of the RNA strand from degradation. Splicing removes no...
Matys V, Kel-Margoulis OV, Fricke E, Liebich I, Land S, Barre-Dirrie A, Reuter I, Chekmenev D, Krull M, Hornischer K: TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 2006, D108-110. 34 Database Bryne JC, Valen E, Tang MH, ...
Identifying potential resistance mechanisms while tumour cells still respond to therapy is critical to delay acquired resistance. We generated the first comprehensive multi-omics, bulk and single-cell data in sensitive head and neck squamous cell carcino
Given the aggressive nature and robust survival capabilities of the alligator gar (Atractosteus spatula), if it was to exist in a new environment as an invasive species, it could cause significant disruption to the invaded ecosystem. Building on the continuity and completeness of the existing draf...
Experimentally validated data on gene regulation are hard to obtain. In particular, information about transcription factor binding sites in regulatory regions are scattered around in the literature. This impedes their systematic in-context analysis, e.g.
Topoisomerases resolve torsional stress, while their function in gene regulation, especially during cellular differentiation, remains unknown. Here we find that the expression of topo II isoforms, topoisomerase IIα and topoisomerase IIβ, is the charact
Author notes J. Chappell Present address: Department of Biochemistry C-016, University of California, 92093, San Diego, La Jolla, CA, USA Authors and Affiliations Max-Planck-Institut für Züchtungsforschung, 5000, Köln 30, Germany K. Hahlbrock & D. Scheel ...
Author notes Chunli Mao and Jian Zhang contributed equally to this work. Authors and Affiliations College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China Chunli Mao, Yaning Zhang, Bixian Wang, Weihang Li, Xiaoshan Wang & Linkai Huang Sichuan Provincial For...
Horizontal gene transfer, the exchange of genetic material through means other than reproduction, is a fundamental force in prokaryotic genome evolution. Genomic persistence of horizontally transferred genes has been shown to be influenced by both ecolog
Supplementary Notes 1 and 2 and Supplementary Table 1. Reporting Summary Rights and permissions Reprints and permissions About this article Cite this article Si, X., Zhang, H., Wang, Y. et al. Manipulating gene translation in plants by CRISPR–Cas9-mediated genome editing of upstream open readi...