Regulation of gene transcription is the primary means by which gene expression is controlled to produce different proteins in different cell types or in response to different stimuli. This process is controlled by transcription factors that belong to specific families which are defined on the basis ...
The graph shows relative expression of firefly luciferase expressed from the SMN2-on or indSMN2-on cassettes in cells treated with DMSO or LMI070 (100 nM). The activity of the transfection control Renilla luciferase cassette is represented as a line above the bar graph. Data are the mean ±...
N. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 15, 509–524 (2014). CAS PubMed Google Scholar Motino, O. et al. Regulation of microRNA 183 by cyclooxygenase 2 in liver is DEAD-box helicase p68 (DDX5) dependent: role in insulin signaling. Mol. Cell. Biol. 35,...
It is therefore no surprise that both neoplasia and many developmental pathologies involve lesions in the regulation of specific genes. For this reason, an understanding of how genes are regulated has become an area of intense interest in both medicine and biology. 展开 ...
分子生物学教学课件:CHAPTER 16 Molecular Biology of the Gene.ppt,Chapter 16 Gene Regulation in Prokaryotes Transcription initiation Elongation and termination: Antitermination and beyond Regulatory proteins Gene Expression is Controlled by Regulatory Pro
Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. The tetracycline (Tc) responsive regulatory systems have been applied to control gene activities in eukaryotes. They are shown to function in cultured cell... U Baron,H Bujard - 《Methods in ...
Moreover, sodium-dependent repetitive firing in Drosophila neurons is regulated by TipE [12], and Para-TipE interactions influence the pharmacology of the Para NaV channel [13]. Despite the lack of insect orthologues of vertebrate NaV channel auxiliary beta-subunits, characterization of the D. ...
The presence of gene-specific repressors in eukaryotes is known. The extent of their occurrence is not. It is often assumed that GSTFs in eukaryotes are predominantly activators (Fuda et al., 2009, Struhl, 1999). This is in part based on the idea that the chromatinized DNA found in ...
We performed a genome-wide analysis of gene expression in C. elegans to identify germline- and sex-regulated genes. Using mutants that cause defects in ger... V Reinke,IS Gil,S Ward,... - 《Development》 被引量: 743发表: 2004年 Codon Usage and tRNA Genes in Eukaryotes: Correlation of...
Gene expression is regulated by multiple processes, and the translation of mRNAs into proteins is an especially critical step. Upstream open reading frames (uORFs) are widespread cis-elements in eukaryotic genes that usually suppress the translation of downstream primary ORFs (pORFs). Here, we desc...