The retinal tissues of the NHPs retinas after suprachoroidal injection were isolated and the anti-VEGF protein expression level were measured. A higher concentration of the anti-VEGF protein was found in the AAVv128-treated NHP retinal tissue and other tissues, with levels of 2112 ng/g (OS...
The retinal tissues of the NHPs retinas after suprachoroidal injection were isolated and the anti-VEGF protein expression level were measured. A higher concentration of the anti-VEGF protein was found in the AAVv128-treated NHP retinal tissue and other tissues, with levels of 2112 ng/g (OS...
Rapid progress in genetic engineering of plants has opened vistas for manipulation of traits to not only meet the ever-increasing need of food, feed, and fuel but also produce novel compounds in transgenic plants (genetically modified crops or GM crops).
Our analysis of this comprehensive data set identified both protein-coding and non-coding HIF1A target genes as part of the acute response and produced several mechanistic insights. Hypoxia induces acute transactivation and repression in a HIF1A-dependent manner, but only transactivation is associated ...
MEME Suite was used to determine all motifs in the CaBBX protein sequences [48]. Analysis was per- formed using the following parameters: number of rep- etitions, if any; optimum width of the motif, 6–50; and maximum number of motifs, 8. And the intron and exon were determined by ...
[92] have shown that the disruption of SNARE complexes and vesicle trafficking resulting from the significant accumulation of abnormal α-SNAP protein at the syncytium confers resistance. Moreover, an unusual NSF allele (rhg1-associated NSF on chromosome 07; NSFRAN07) was discovered only in rhg...
Olfaction is a complicated process; it begins in the olfactory epithelium with the specific binding of volatile odorant molecules to dedicated ORs expressed by olfactory sensory neurons (OSNs) [2–5]. OR proteins are encoded by the largest gene superfamily in the mammalian genome. Using the ...
LVs typically contain a double-stranded RNA core along with a reverse transcriptase protein for conversion of the RNA payload to double-stranded DNA, allowing the latter to be incorporated within the infected host cell nucleus. LVs integrate into non-dividing as well as dividing cells, including ...
RdDM has also been shown to regulate protein-coding genes [9,10], but this aspect of RdDM function has not been well studied, and very few RdDM-targeted genes have been identified. Much effort over the past decade has been attributed to the characterization of the components and the ...
Methylation of cytosines at the ICR inhibits binding of the zinc finger protein CTCF to the paternal allele, preventing its role as an insulator and allowing long-range interactions of the IGF2 promoter with enhancer elements downstream of the H19 gene [9–11]. In contrast, the unmethylated ...