somatic mutationparadoxical antagonistic pleiotropylate‐acting constitutional mutationsWhat might now be referred to as the "classical" evolutionary biological theory of why we age has had a number of serious challenges in recent years. While the theory might therefore have to be modified under certain...
Once, we thought we understood all there was to know about how gene expression is regulated: A cell can tinker with the expression level of a given protein’s messenger RNA by modifying the activity, abundance, and type of transcription factors in the nucleus or with the RNA’s stability on...
Interestingly, mice with null mutation in the gene MGRN1 (mahogunin, ring finger 1) which encodes E3 ubiquitin ligase show dark coat color and produce only eumelanin (dark, brown-black melanin) but not pheomelanin (light, red-yellow melanin) (He et al., 2003). Furthermore, ubiquitin-...
In theory, we should detect double peaks for all proteoforms that are common for AHSG*1 and AHSG*2. Nevertheless, because of the very small m/z difference between both AHSG genes (16 Da, i.e. 1.23 Th for the 13+ charge state), we observed in practice broader or partially split peaks...
Moreover, the gene frequency of IGF-1 c.258 A > G among pigs with different body size was excavated according to the whole-genome shotgun contigs (gws) and RefSeq genome databases. Results found that codon usage preference for this synonymous mutation was significant between the large and ...
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Aging is a convoluted process that is consistent with the multiplicity aspect of biology, and several aging hypotheses have been proposed1. The “mutation accumulation” hypothesis proposed by Dr. Medawar estimates that late-acting deleterious germline mutations exhibit only a slight influence after matu...
This strain carries a tetK-labeled csa1 locus where each gene is inactivated by a single nonsense mutation (Supplementary Fig. 3a). Passaging of this strain in the presence or absence of CIP revealed a similar pattern of amplification as observed for the functional locus, supporting the idea ...
A challenge in bulk gene differential expression analysis is to differentiate changes due to cell type-specific gene expression and cell type proportions. SCADIE is an iterative algorithm that simultaneously estimates cell type-specific gene expression p
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