Advances in understanding the biology of rheumatoid arthritis (RA) haveopened new therapeutic avenues. One of these, gene therapy, involves thedelivery to patients of genes encoding anti-arthritic proteins. Thisapproach has shown efficacy in animal models of RA, and the first human, phase Itrial ...
Makarov SS. Gene therapy for rheumatoid arthritis: preclinical studies. In Evans CH, Robbins PD, eds. Gene therapy in inflammatory diseases. Basel: Birkhäuser; 2000:13--34Sergei S.M., Gene therapy for rheumatoid arthritis: preclinical studies. Gene Therapy in Inflammatory Diseases Progress in ...
Current understanding of the pathogenesis of rheumatoid arthritis has provided evidence that therapeutic benefit can be achieved by using antagonists targeted to the inflammatory cytokines involved, mainly tumour necrosis factor-α and interleukin-1. Gene delivery of antagonists, which can inhibit the produ...
Additionally, the same eQTL variant colocalized with association signals for rheumatoid arthritis and celiac disease, in agreement with the CTLA4-based therapies used in rheumatoid arthritis37 (Supplementary Table 9). Finally, we asked whether immune disease loci affected specific cellular functions. Co...
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease of the joint, affecting 0.24% of the global population. Many patients only respond partially or not at all to current therapies while the systemic complications of immunosuppression associated with these treatments are unacceptable. Genetic...
et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45, 1452–1458 (2013). CAS PubMed PubMed Central Google Scholar Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, ...
[44]. Lentiviral vectors may have this potential as well as sharing a similar mechanism, although this has never been demonstrated in clinical studies. More recently, in July of 2007, Jolee Mohr, a patient enrolled in Targeted Genetics’ clinical trial for rheumatoid arthritis using AAV vectors,...
Hazelwood6, CL Verweij3, A Rowe7, GN Goulielmos8, LGM van Baarsen9 and F Ponchel1 Gene expression has recently been at the forefront of advance in personalized medicine, notably in the field of cancer and transplantation, providing a rational for a similar approach in rheumatoid arthritis (...
Prickett and Jain summarize advances in gene transfer and gene repair of the cystic fibrosis transmembrane regulator gene, and a new perspective on the gene therapy of rheumatoid arthritis and osteoarthritis is given by Evans, Ghivizzani, and Robbins. Looking forward, this information will be ...
To explore the association between HLA-DRBl gene mutations and rheumatoid arthritis, Viatte's team used imaging data collected on more than 2,100 patients to evaluate the severity of the disease. They evaluated the risk of death in more than 2,400 patients and the effectiveness of TNF inhibito...