Gene flow, the exchange of genetic material between populations is an important biological process, which shapes and maintains biodiversity. The successful movement of individuals between populations depends on multiple factors determined by species biology and the environment. One of the most important ...
Although research in some systems has brought insights into the nature of hybridization, detecting and quantifying interspecies gene flow is surprisingly difficult. Until recent advances in sequencing technologies, scientists relied on phenotypic characters to study hybridization, which sometimes yielded results...
The most recent Alu insertions reveal different degrees of polymorphism in human populations, and a series of characteristics that make them particularly suitable genetic markers for Human Biology studies. This has led these polymorphisms to be used to analyse the origin and phylogenetic relationships be...
When we look at gene therapy from the viewpoint of a gene itself, we may not grasp the gene in the context of a cell, a tissue, or an organism that together give the gene its physiological meaning. Bioinformatics models the complex interactions among genes, cells, tissues, individuals, and...
Genetic diversity, genetic structure, and gene flow in plant populations and their influencing factors are important in conservation biology. Cypripedium macranthos is one of the few wild orchids with high ornamental value in northern China. However, over the past decade, excessive collection, trading...
Understanding the genetic regulatory code governing gene expression is an important challenge in molecular biology. However, how individual coding and non-coding regions of the gene regulatory structure interact and contribute to mRNA expression levels r
The biological meaning of such association is unclear but the extended MHC regions contain many other olfactory genes [14] and olfactory dysfunction has already been reported in Multiple Sclerosis [15]. At FDR threshold of 50% and after exclusion of bins from MHC, the method selects ten bins....
The graph was undirected, meaning some routes could be bidirectional. A small branch of the network inside the blue rectangle was zoomed out for illustration purpose. The complete list of pathways and GOBP can be viewed in Supplemental Table 1. We observed that all 7 pathways in those 6 ...
(0,x)\). The reason to design such an equation to representSrather than a single matrix is that more parameters could enable the model to learn a good signature matrix more quickly and easily, and the ReLU(⋅) function is used to ensure the biological meaning of the signature matrix. ...
(dashed line inFigure 2; ρ=0.95,P=2.67 × 10−11). This 22 is a much greater number than expected by chance; theP-value for having the same 22 genes shared by both methods was 0.004. Half of the 22 genes had a negative log2FC value, meaning they were upregulated in lakes, ...