Nachtomy O, Shavit A, Yakhini Z (2007) Gene expression and the concept of the phenotype. Stud. Hist. Phil. Biol. & Biomed. Sci. 38: 238-254Nachtomy O, Shavit A, Yakhini Z. Gene expression and the concept of the phenotype. Stud Hist Philos Biol Biomed Sci 2007;38:238e54....
Cells in 2D are known to differ from their in vivo counterparts in cell shape, proliferation, and gene expression. Little is so far known about the phenotype and gene expression of cells in three-dimensional (3D) culture systems. To begin to unravel the impact of 3D versus 2D culture ...
The ability to independently control the expression of different genes is important for quantitative biology. Here, the authors report kinetic parameters, noise scaling, impact on growth, and the fundamental leakiness of a wide range of inducible transcriptional systems, including a new, highly light...
An understanding of the genetic architecture behind polyphenisms provides a novel means of studying the interplay between genomes, gene expression and phenotypes. Here we discuss polyphenisms and molecular genetic tools now available to unravel their developmental bases in insects. We focus on several ...
Modules with heritability ≥0.05 and gene counts ≥5 were used for multiple regression of gene expression to phenotypic values across timepoints. For each module, the degree of correlation between gene expression and phenotype at a given timepoint was indicated by the magnitude of the normalized ...
作者: Jung Kyoon Choi and Sang Cheol Kim 摘要: Phenotypic discordance between monozygotic twins, such as a difference in disease susceptibility, implicates the role of the environment in determining phenotype. To assess genomewide environmental effects on "gene expression phenotype," we employed a ...
ofproteinsand their organization into a living body—the soma. Modern understanding of phenotype, however, is derived largely from the work of Danish botanist and geneticistWilhelm Ludvig Johannsen, who in the early 20th century introduced the termphenotypeto describe the observable and measurable ...
Objective To get more insight into progression of diabetic nephropathy (DN) and select individual genes associated with the progression of the disease. Methods Ten patients diagnosed as type 2 DN were included in the study. They were divided based on their clinical phenotype. Five donor kidneys se...
Multi-omic Analysis for Directly Linking T Cell Phenotype to Gene Expression 杨晨 中国科学院 细胞生物学博士Multi-omic Analysis for Directly Linking T Cell Phenotype to Gene Expression发布于 2021-06-17 20:01 内容所属专栏 基因云 基因云-加速新药研发,肿瘤新生抗原 订阅专栏...
Its molecular basis is not entirely clear, although profound gene expression changes have been reported, and there are some known and other presumed overlaps with normal aging process. Identification of genes with aging - or HGPS-associated expression changes is thus an important problem. However, ...