of a transcription factor, among others. In some cases, the promoter can be targeted to disrupt gene function; however, because cryptic promoters may be present that can take over and drive expression even after the core promoter is deleted, protein coding regions of genes are generally ...
The growth of tumor xenografts was significantly retarded on the mice treated with pcDNA3.1-RBM5 carried by attenuatedSalmonellacompared to that on mice treated with pcDNA3.1. Overexpression of RBM5 enhanced the apoptosis in tumor xenografts. Furthermore, the expression of Bcl-2 protein was ...
12). To test the role of these loci in molecular profiles, we performed colocalization for depression and multi-ancestry brain expression quantitative trait loci (eQTLs)27. Loci with posterior probability (PP) >90% for both traits being associated and sharing two different but linked variants (...
Expression of Nucleostemin Gene in Human Acute Leukemic CellsNo article summary included中国解剖学会;河南省解剖学会;河南省生理学会;河南大学;郑州大学International Symposium on Interdisciplinary Life Sciences from Genome to Function
Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. We characterize SPOC as a CTD reader domain that preferentially binds two phosphorylated Serine-2 marks in adjacent CTD repeats. PHF3 drives ...
AnnexinV analysis was performed by flow cytometry. Expression of Bcl-2, cleaved caspase-3, caspase-9 and PAPP proteins in A549 lung cancer cells and the A549 xenograft BALB/c nude mice model was determined by Western blot. Tumor suppressor activity of RBM5 was also examined in the A549 ...
Recent studies have indicated that the nuclear RNA-binding protein RBM5 has the ability to modulate apoptosis and suppress tumor growth. The aim of this study is to investigate the expression of RBM5 in human prostate cancer and its mechanism of tumor suppression. Methods The expression of RBM5...
Deep transcriptional sequencing (RNA-Seq) now makes it possible to study the occurrence and expression levels of TICs in individual samples across the genome. Methods We performed single-end RNA-Seq on three human prostate adenocarcinoma samples and their corresponding normal tissues, as well as ...
cases. IMPC data for the first mouse knockout of the orthologousTmem63bgene showed preweaning lethality of the homozygotes and, in the case of the heterozygotes, abnormal behaviour, hyperactivity and limb-grasping phenotypes that are consistent with the human patients. Expression analysis placedTMEM...
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation...