The genes (and) have a key role in glucose-stimulated insulin secretion and thus have always been considered as excellent susceptibility candidates for involvement in type 2 diabetes. Common polymorphisms (E23K andexon16-3t/c) in these genes have been reported to be associated with type 2 ...
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for...
Serum Levels of Adiponectin are Associated with Diabetic Retinopathy and with Adiponectin Gene Mutations in Caucasian Patients with Diabetes Mellitus Type 2 INTRODUCTION: Even diabetic patients with excellent glycemic control can develop diabetic complications very early. Possibly, not only the degree of gl...
Cancer treatment has evolved significantly within the past decade, with advancements in chemotherapy, radiotherapy, targeted therapies, and immunotherapy. However, the development of resistance to these treatments remains a significant challenge. …
Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads ...
However, the TAC (BAt) haplotype was associated with increased odds of MDD (adjusted OR = 2.17, 95% CI = 1.30–3.61, p = 0.003) using CCT (baT) as reference haplotype. The findings suggest that the BsmI-ApaI-TaqI TAC (BAt) haplotype of the VDR gene increases ...
Foelsch Æ Frank Doering Juergen Schrezenmeir A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels Received: 4 November 2005 / Accepted: 28 February 2006 / Published online: 24 ...
www.nature.com/scientificreports OPEN received: 23 June 2015 accepted: 07 July 2016 Published: 28 July 2016 Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population Dan Ye1,*,Yang Fei2,*, Qi Ling3, Weiwei Xu1, Zhe Zhang1, Jing...
and rs2237897, to be associated with type 2 diabetes. These results are consistent with previous ...
Conclusion Delete polymorphism of A1166 C gene is associated with DN in type 2 diabetes mellitus. It is suggested that detection of significiant AGTⅠR A1166 C polymorphism is of help for preventing DN in type 2 diabetes mellitus. 展开 关键词: Angiotensin converting enzyme Diabetic nephropath...