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In contrast, TALEN usage is not dependent on the availability of a PAM site and can be used at any location in the genome. Closer proximity of the TALENs to the target insertion site can also lead to improved homology-directed repair (HDR). Although TALEN may have more specific and flexibl...
- . ID=gene-EEW87_RS00020;Dbxref=GeneID:59160220;Name=EEW87_RS00020;gbkey=Gene;gene_biotype=protein_coding;locus_tag=EEW87_RS00020;old_locus_tag=EEW87_003565 NZ_CP044548.2 Protein Homology CDS 2010 3521 . - 0 ID=cds-WP_123091172.1;Parent=gene-EEW87_RS00020;Dbxref=GenBank:WP_...
In contrast, TALEN usage is not dependent on the availability of a PAM site and can be used at any location in the genome. Closer proximity of the TALENs to the target insertion site can also lead to improved homology-directed repair (HDR). Although TALEN may have more specific and flexibl...
prominent—and then SVs and CNVs at much lower frequencies (Fig.2b). Despite their lower abundance, SVs and CNVs can affect a significant fraction of protein-coding genes (Fig.2c), highlighting their relevance. We investigated the mechanisms underlying the formation of SVs and CNVs, and found...
Roughly 10% of Cystic Fibrosis (CF) patients still have no effective medicine to take. Lung Selective Organ Targeting (SORT) Lipid Nanoparticles can efficiently deliver Cas9 mRNA, sgRNA, and donor ssDNA templates for precise homology-directed repair-mediated gene correction in ex vivo and in vivo...
CRISPR 101: Cytosine and Adenine Base Editors Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR), the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ), HDR occurs...
This application is used to predict antibiotic resistome(s) from protein or nucleotide data based on homology and SNP models. The application uses reference data from the Comprehensive Antibiotic Resistance Database (CARD).RGI analyses can be performed via the CARD website RGI portal, via use of...
Comparison of protein homology between the APOBEC3B gene and the other genes.KengHoong, NgChinKuan, HoSomnuk, PhonAmnuaisuk
CRISPR-based active genetic elements, or gene-drives, copied via homology-directed repair (HDR) in the germline, are transmitted to progeny at super-Mendelian frequencies. Active genetic elements also can generate widespread somatic mutations, but the ge