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manipulation of autologous lymphocytes, the emerging application of genome editing technology has demonstrated that allogeneic TCRαβ cells can be engineered to overcome Human Leukocyte Antigen (HLA) barriers and provides a route to more cost effective and widely accessible 'off-the-shelf' therapies. ...
1.基因编辑(gene editing),又称基因组编辑(genome editing)或基因组工程(genome engineering),是对生物体基因组特定目标基因进行修饰的一种基因工程技术。基因编辑技术指能够让人类对目标基因进行定点 “编辑”,实现对特定DNA片段的修饰。基因编辑技术可以利用基因编辑工具去除或减弱不利于农艺性状的基因,还可以增强众多...
Gene and Genome Editing Articles in press This journal currently does not have articles in press Note to users: Articles in press are peer reviewed, accepted articles to be published in this publication. When the final article is assigned to volumes/issues of the publication, the article in pre...
Journal of Nanobiotechnologyis calling for our collection on Advances in Nanomaterials for Gene Therapy and Genome Editing. Gene therapy and genome editing are at the forefront of modern medicine, with remarkable potential to impact the prevention, intervention, and diagnosis of a wide range of diseas...
The Inaugural Renaissance of Gene Therapy and Genome Editing conference program at the 27th International Molecular Medicine Tri-Conference will showcase topics spanning fundamental research, genome editing (CRISPR and zinc-finger nucleases), preclinical
Genome Editing Learning Center Genome Editing Support Center A complete CRISPR and TALEN gene editing toolkit To help researchers in their quest to understand how the genome influences phenotype, we’ve developed a complete set of trusted solutions for every step in the gene editing workflow. Desig...
摘要: Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 is a putative male determination gene, but direct genetic evidence is still lacking.DOI: 10.1038/srep42213 被引量: 32 ...
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Building off the foundation laid by a decade of ZFN-induced genome editing, the discovery of TALEs as a programmable DNA-binding domain was rapidly followed by the engineering of TALENs. Like ZFNs, TALEs were fused to the catalytic domain of the FokI endonuclease and shown to function as dimer...