Polysomy for chromosome #7, in contrast, occurred in 58% of tumors with EGFR amplification and 53% of tumors without amplification of the gene. Structural abnormalities of 7p occurred in two tumors with EGFR amplification and in one tumor without amplification of this gene. These studies suggest...
In addition, epigenetic control is responsible for X-chromosome inactivation in women that guarantees they have the same number of X-chromosome gene products as do men.9 mRNA Processing (Splicing) Splicing is the pre-mRNA processing mechanism by which introns are removed and exons are joined ...
Chromatin is highly organized within discrete chromosome territories, into compartments of active or inactive chromatin, self-interacting domains, and loops between specific loci (reviewed in refs. 1,2). However, the relationship between the three-dimensional (3D) organization of chromatin and the regu...
Extreme independent variation in the expression of pairs of HLA-associated transcripts (HLA-B/C, HLA-A/F and HLA-DRB1/DRB5) in macrophages was associated with HLA genotype. Correlation analysis indicated the downstream impacts of variation in the immediate early response to LPS. For example, ...
[39–46]. Nevertheless, a clear association between promoter nucleotide sequences and chromosome territories was never hypothesized. The purpose of our work was to establish a possible functional significance of promoter sequences which may explain the dynamic relationship between different chromosome ...
D. et al. Molecular mechanisms and evolutionary processes contributing to accelerated divergence of gene expression on the Drosophila X chromosome. Mol. Biol. Evol. 32, 2605–2615 (2015). CAS PubMed PubMed Central Google Scholar Nica, A. C. & Dermitzakis, E. T. Expression quantitative ...
In the presence of horizontal gene transfer (HGT), the concepts of lineage and genealogy in the microbial world become more ambiguous because chimeric genomes trace their ancestry from a myriad of sources, both living and extinct. We present the evolutio
a technology referred to as SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution). Several applications of SCRaMbLE for the improvement of industrial production traits have been reported in recent years, demonstrating the potential and importance of structural variation for...
An association has been reported between a specific haplotype of the JAK 2 gene, the homozygous 46/1 haplotype, and a predisposition to the development of chromosome Philadelphia-negative myeloproliferative neoplasms. Concerning myelofibrosis (MF), controversy remains on the relationship between the above...
Ghozi, et al., "Isolation, Chromosomal Localization, and Sequence Analysis of Human Chromosome 21 Zinc Finger Domains" Genomics 20:487-489 (1994). Griggs, et al., "Hereditary paroxysmal ataxia: Response to acetazolamide" Neurology 28:1259-1264 (1978). Hastbacka, et al., "Linkage disequil...