The very long strand of DNA which further contains many genes (hundreds to thousands) makes up a chromosome. The genes are arranged in a particular sequence and have a particular location on the chromosome (called its locus). In addition to DNA, chromosomes also contain man...
The relationship between gene and chromosome mutations in cultured Chinese hamster cells exposed to aflatoxin B1: Velázquez, A., C. de Nava, R. Coutiño and I. Pulido Institute of Biomedical Research, National University of Mexico, Mexico City (Mexico)...
In addition, epigenetic control is responsible for X-chromosome inactivation in women that guarantees they have the same number of X-chromosome gene products as do men.9 mRNA Processing (Splicing) Splicing is the pre-mRNA processing mechanism by which introns are removed and exons are joined ...
To do this, we first separated genes into two groups: “expressed” genes with RPKM ≥ 1 and “unexpressed” genes with RPKM < 1. We held out genes on one chromosome at a time as a test set and used genes on all other chromosomes as a training set. We calculated the ...
Chromatin is highly organized within discrete chromosome territories, into compartments of active or inactive chromatin, self-interacting domains, and loops between specific loci (reviewed in refs. 1,2). However, the relationship between the three-dimensional (3D) organization of chromatin and the regu...
a technology referred to as SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution). Several applications of SCRaMbLE for the improvement of industrial production traits have been reported in recent years, demonstrating the potential and importance of structural variation for...
(2014) performed similar experiments on Bph1 resistance using pure inbred lines of BPH and reported that antixenosis (host preference) is governed by a single gene on chromosome 7, but antibiosis (growth rate) is governed by two major QTLs on chromosomes 5 and 14, indicating that virulence...
eVariants (10% FDR) were enriched in cell-type matched enhancers (median Fisher’s exact test, P ≤ 2.2 × 10−3) but not strongly enriched for promoters (median P ≤ 0.22), compared to randomly selected variants matched by distance to nearest TSS, MAF and chromosome (...
[39–46]. Nevertheless, a clear association between promoter nucleotide sequences and chromosome territories was never hypothesized. The purpose of our work was to establish a possible functional significance of promoter sequences which may explain the dynamic relationship between different chromosome ...
Tyrosine kinase inhibitors have been the standard treatment for patients with Philadelphia chromosome-positive (Ph+) leukemia. However, a series of issues, including drug resistance, relapse and intolerance, are ... Yanzi Sun, Yishu Wang, Chunyan Liu, Yingshuang Huang, Qiulin Long, Caoyun Ju, Ca...