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In conclusion, gender-specific differences in the response to AKI in αMUPA mice include multifaceted and keen interactions between the sex hormones and key biochemical mediators (such as estrogen, testosterone and eNOS). These novel findings shed light on the renoprotective pathways and mechanisms, ...
Since the turn of the century, we are witnessing a dramatic surge in the numbers of children and adolescents referred to gender clinics, this is happening in the context of general increase in numbers of individuals identifying as non-binary. The chapter
In animal research, females and males are often studied separately in the laboratory. Yet in the wild, the sexes coexist—and their interactions can influence research results. Recent studies of longevity in the nematode, Caenorhabditis elegans, found that the presence of males accelerated ageing in...
Gametogenesis in general and egress from the host RBC are tightly coordinated processes, central for transmission to the mosquito vector (9, 10). Molecules/pathways involved in these crucial steps of the parasite life cycle may represent novel promising targets for effective transmission-blocking ...
Although the role of distinct T cell subsets in OA is largely unknown, it has been suggested that they may shape the balance between inflammatory and non-inflammatory pathways contributing to OA. In CD8+ T cell knockout mice, the cartilage degeneration was slower than in the wild type22. ...
Lef1 haploinsufficiency also led to low bone mass in males lacking functional androgen receptor (AR) (tfm mutants). The protective skeletal effect of AR against Wnt-related low bone mass is not necessarily a result of direct interaction between the AR and Wnt signaling pathways, because Lef1+/...
Numerous interactions, such as the interaction of the sex of the research participants, may also influence outcomes. In animal research, females and males are often studied separately in the laboratory. Yet in the wild, the sexes coexist—and their interactions can influence research results. Recent...
By analyzing the common pathways between DAMs and differentially expressed genes, we found that gender-related genes of H. leucospilota were mostly enriched in the necroptosis pathway and the cysteine and methionine metabolism pathways. According to the common pathways, uch-sc1 and uch-sc2 are ...
“This is an election that I believe — and I think the way that she thinks about what she is doing in this moment — it is bigger than just her gender or her race,” Butler said. “I fundamentally believe and know in her heart that she is doing this because she knows...