方法 采用MTT比色分析法测定4株SCLC~Itt胞株和6株NSCLC细胞株对CDDP和GEM的 药物敏感性,同时应用cDNAmacroarray:~[术检测l0株肺癌细胞株 中l291个药物敏感性相关基因的表达状态 ,分析二 者之间的相关性。结果 与GEM药物敏感性呈明显正相关 (r≥o.632,P0.05)的基 因有6个 ;~CDDP药物敏感性关联 的基 因...
摘要: 背景与目的 筛选小细胞肺癌(small cell lung cancer,SCLC)和非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞株中与健择(gemcitabine hydrochloride,GEM)和顺铂(cisplatin,CDDP)药物敏感性相关的基因,有助于进一步阐明抗癌药物作用机制,为克服抗癌药物的耐药性,... 查看全部>>关键词:...
CDDP背景与目的筛选小细胞肺癌(small cell lung cancer,SCLC)和非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞株中与健择(gemcitabine hydrochloride,GEM)和顺铂(cisplatin,CDDP)药物敏感性相关的基因,有助于进一步阐明抗癌药物作用机制,为克服抗癌药物的耐药性,研制开发新的抗癌药物提供新线索,同时也将为临床的...
Apoptosis-inducing activity of cisplatin (CDDP) against human hepatoma and oral squamous cell carcinoma cell lines. The sensitivity of human hepatoma (HepG2) and oral squamous cell carcinoma (HSC-2) cell lines against various apoptosis-inducing agents was compared. HepG2... M Okamura,K Hashimoto...
Gemcitabine (dFdC) can increase the sensitivity of both cisplatin (CDDP)-sensitive and -resistant cell lines. It has been postulated that both formation and repair of platinum-(Pt)-DNA adducts are related to these effects. Therefore, we investigated the effects of dFdC on the formation and repa...
To observe the effect of thalidomide in preventing nausea and vomiting induced by emetogenic cisplatin (CDDP) chemotherapy in patients with advanced non-sm... YL Yu,ZT Zhu,JP Li,... - 《Zhonghua Zhong Liu Za Zhi Chinese Journal of Oncology》 被引量: 7发表: 2009年 Study ESOGIA-GFPC 08...
γ-聚谷氨酸-顺铂复合物(γ-PGACA-CDDP) 聚谷氨酸-g-聚乙烯亚胺 PEI-g-PGA 聚酰胺-胺-聚谷氨酸-聚乙烯亚胺共聚物 马来酰亚胺聚谷氨酸天冬氨酸(Mal-PGA-Asp) 聚谷氨酸苄酯-b-聚乙二醇(PBLG-b-PEG) 聚乙二醇-聚亮氨酸-聚谷氨酸(PEG-PLeu-PGA)
‣Pierre, Directeur de CDDP : "Les applications eduPad répondent à un besoin d’aide aux devoirs et de continuité pédagogique à la maison. Elles sont extrêmement simples et intuitives à utiliser pour les élèves et la famille ». ‣ Bernard, chef de projet Ordicollège : «...
Grigorescu AC,Draghici IN,Nitipir C,et al.Gemcitabine (GEM) and carboplatin (CBDCA) versus cisplatin (CDDP) and vinblastine (VLB) in advanced non-small-cell lung cancer (NSCLC) stages Ⅲ and Ⅳ: a phase Ⅲ randomised trial.Lung Cancer. 2002...
Ricci S, Antonuzzo A, Galli L, Bonifazi V, Lopes Pegna A, Algeri R, Petruzzelli S, Santomaggio C, Ghezzi P, Bertuccelli M, Tibaldi C, Innocenti F, Barsanti G, Roggi G, Conte PF: Combination chemotherapy with two different schedules of Gemcitabine (GEM) plus Cisplatin (CDDP) in ...