Intra-articular drug deliveryRheumatoid arthritis(RA)is a chronic inflammatory and destructive arthropathy with a high deformity rate.Despite numerous studies and clinical trials,no curative treatment is available for large weight-bearing joints.Intra-articular(IA)injections could deliver high concentrations ...
Therefore, in the medical profession, doctors often give arthritis patients intra-articular injections of sodium hyaluronate to supplement and improve the viscosity and elasticity of the joint fluid, which acts as a shock absorber as well as a lubricant to further protect the cartilage in the jo...
Therefore, in the medical profession, doctors often give arthritis patients intra-articular injections of sodium hyaluronate to supplement and improve the viscosity and elasticity of the joint fluid, which acts as a shock absorber as well as a lubricant to furt...
Glycosylation and gene expression-based differences between responders and nonresponders in rheumatoid arthritis for anti-TNF-α treatment. (A) A2(3)G1 (biantennary monogalactosylated), (B) A2B(3)G1 (biantennary monogalactosylated with bisecting GlcNAc), (C) FA2B(3)G1 (biantennary mono...
T cells were then isolated from the collected blood using an integrated chip for the preparation of ABGD cell formulations. Subsequently, melanoma-bearing mice in the group β received injections of PBS, droplet-encapsulated T cells (T cells in droplet), ABGD (No cells in the droplet), and ...
The safety of Restylane for use during pregnancy, in breastfeeding females or in patients under 18 years has not been established. Formation of keloids may occur after dermal filler injections including Restylane. Keloid formation was not observed in studies involving 430 patients (including 151 Afric...
The following adverse events are among those that may occur in association with intra-articular injections. Arthralgia Joint stiffness Joint effusion Joint swelling Joint warmth Injection site pain Arthritis Arthropathy Gait disturbance According to post-marketing experience of other sodium hyaluronate prepara...
Therefore, in the medical profession, doctors often give arthritis patients intra-articular injections of sodium hyaluronate to supplement and improve the viscosity and elasticity of the joint fluid, which acts as a shock absorber as well as a lubricant to further protect the cart...
Hertzberger-Ten Cate et al., “Intra-Articular Steroids in Pauciarticular Juvenile Chronic Arthritis”, Type I, Eur J Pediatr; vol. 150; pp. 170-172; 1991. Hetherington, “Potential for Patient Harm From Intrathecal Administration of Preserved Solutions”, Abstract only Med J; vol. 173(3)...
Though vitreous injections containing HA, for example, which contain at least 1.5 wt %, preferably from 2 to 2.5 wt % of HA with a molecular weight of at least 900000, preferably 1600000 to 2000000 are disclosed in JP-A-5-184663, they are not retained in the intraocular space {Nippon Ga...