GDP-mannose (GDP-Man) is the central activated sugar nucleotide for mannosylation and is essential for the biosynthesis of N -linked glycoproteins and glycosylphosphatidylinositol anchors (GPI-anchors) in eukaryotes as well as for the formation of bacterial capsular lipopolysaccharides. In addition, ...
(1994). GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aerug- inosa: evidence from metabolite studies. Microbiology 140, 1745-1754. doi: 10.1099/13500872-140-7-1745Tatnell, P. J., N. J. Russell, and P. Gacesa. 1994. GDP-mannose dehydro- ...
The recently identified GDP-Man 3',5'-epimerase catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C, resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Here, we characterize the native and ...
In eukaryotes, the enzyme GDP-mannose pyrophosphorylase (GDPMP) is essential for the formation of GDP-mannose, the central activated mannose donor in glycosylation reactions. Deletion of its gene is lethal in fungi, most likely as a consequence of disrupted glycoconjugate biosynthesis. Furthermore, ...
然而,GDP-甘露糖是在细胞质上产生的,GDP-甘露糖必须依赖GDP-甘露糖转运蛋白(GDP-mannose transporter,GMT)从细胞质转运到甘露聚糖合成场所高尔基体上(Bar-peled M,O'Neill M A.Plant nucleotide sugarformation,interconversion,and salvage by sugar recycling.Annual Review ofPlant Biology,2011,62(1):127-155)...
Molecular Cloning of Human GDP-mannose 4,6-Dehydratase and Reconstitution of GDP-fucose Biosynthesis in Vitro * Author links open overlay panelFrancis X. Sullivan 1, Ravindra Kumar 1, Ronald Kriz 1, Mark Stahl 1, Guang-Yi Xu 1, Jason Rouse 1, Xiao-jia Chang 1, Amechand Boodhoo §, ...
GDP-mannose 3 , 5 -epimerase forms GDP-l-gulose, a putative intermediate for the de novo biosynthesis of vitamin C in plants. J. Biol. Chem. 2003, 278, 47483-47490. [CrossRef]Wolucka, B. A. & Van Montagu, M. GDP-mannose 3',5'-epimerase forms GDP-L- gulose, a putative ...
产品介绍: 英文名称:GDP-mannose:cellobiosyl-diphosphopolyprenol α-mannosyltransferase 备注:In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan. In Xanthomonas campestris the enzyme is CB指数: 58 ...
Enzymic synthesis of GDP-mannose- 14 C from mannose- 14 C ☆ A procedure synthesizing GDP-mannose- 14C from mannose using Arthrobacter viscosus crude extracts has been described. J Preiss,E Greenberg - 《Analytical Biochemistry》 被引量: 11发表: 1967年 Biosynthesis of mycobacterial ...
falciparum: UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-Gal, UDP-glucose (UDP-Glc), GDP-mannose (GDP-Man) and GDP-Fuc18. P. falciparum genome encodes and expresses homologues of GMD and FS, the enzymes responsible for the de novo biosynthesis of GDP-Fuc from GDP-Man42. Tritiated fucose ...