文章《Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced byChronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling PreventingHippocampal Neuron Apoptosis》发表在《Frontiersin Cellular Neuroscience》上(影响因子3.900)。 研究简介...
Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson's disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system...
We recently reported that glial cell-derived neurotrophic factor (GDNF)-RET signaling appears to promote a positive feedback loop with the transcription factor early growth response 1 (EGR1). Here we investigate the mechanism behind this feedback loop and test the hypothesis that GDNF-RET ...
To identify possible effectors or regulators of GDNF signaling, we performed a yeast two-hybrid screen using the intracellular domain of RET, the common signaling receptor of the GDNF family, as bait. Using this approach, we identified Rap1GAP, a GTPase-activating protein (GAP) for Rap1, as...
How- ever, despite considerable progress in understanding the RET signaling pathways responsible for cell survival and proliferation, the mechanism underlying RET-mediated neuronal differentiation remains largely unknown. To gain insight into the mechanisms by which GDNF- mediated activation of RET enhances...
The protein phosphatase domain-1 is indispensable for the PTPRA inhibitory role on RET activity and downstream Ras-MAPK signaling, whereas domain-2 has only minor effect. Furthermore, PTPRA also regulates the RET oncogenic mutant variant MEN2A activity and invasion capacity, whereas the MEN2B is ...
Why does GDNF stimulate c-Ret phosphorylation via the transmembrane form of GFRα1, yet does not recruit c-Ret to rafts? Why is c-Ret signaling sustained with soluble GFRα1? It is still unclear, whether soluble forms of GFRα2–4 receptors, mediating NRTN, ARTN and PSPN signaling, ...
GFRalpha1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proc Natl Acad Sci USA. 2014;111:E2008–17. Article CAS PubMed PubMed Central Google Scholar Anand U, Otto WR, Casula MA, Day NC, Davis JB, Bountra C, et al. The effect of neurotrophic ...
From these results, it is suggested that FK962 ameliorates RGC death under H/R, possibly via a GDNF signaling pathway. 显示全部 2024-11-01·American Journal of Physiology-Lung Cellular and Molecular Physiology Effects of glial-derived neurotrophic factor on remodeling and mitochondrial function in ...
关键词: RET; Phosphorylated ribosomal protein S6; Dopaminergic neurons; Prodromal Parkinson?s disease; 年份: 2021 收藏 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文 文献求助 相关文献 Gdnf Signaling In Subjects With Minimal Motor Deficits And Parkinson?s Disease 期刊名:Gdnf Signaling...