1996. Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: a post mortem in situ hybridization study with special reference to Parkinson's disease. J. Neural Transm. 103: 1043-52Hunot, S., Bernard, V., Faucheux, B., Boissiere, F., Leguern, E., ...
研究人员Grant 补充说道:“接受这种基因治疗的猴子开始永久提高多巴胺,并且大大减少了饮酒量。这种治疗手段确实通过手术永久性地改变了大脑,因此仅限于那些患有最严重的酒精使用障碍的人。” The monkeys that were treated with this gene permanently started overexpressing dopamine and they decreased their drinking su...
基因序列:NCBI_Gene:25453 蛋白序列: UniprotKB:A7UGI9 UniprotKB:A7UGJ1 UniprotKB:F8WFL7 UniprotKB:Q07731 大鼠Rat Gdnf 靶点分子功能(预测) Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to...
GDNF基因修饰的骨髓基质干细胞移植治疗大鼠脑出血
The human GDNF gene has been mapped to chromosome 5p13.1-p13.3 .Related factors are Neurturin , Persephin , and Artemin . Collectively they are being referred to as GDNF family ligands . Description : Recombinant Human Glial-derived Neurotrophic Factor (GDNF) produced in E.Coli is a ...
Experiment and Research on Rehabilitation of Injured Peripheral Nerves by Adhering Sutures with Plasmid of GDNF Gene; 携GDNF基因的质粒黏附缝线促进周围神经损伤修复的实验研究 7. Variation and Signification of Glial Cell Line-derived Neurotrophic Factor (GDNF) and GDNF Family Receptor-alpha 1(GFRα1) ...
AbstractObjective:TostudytheprotectiveeffectsofBMSCsmodifiedbyGDNFgene(BMSCs/GDNF)to neuronssubjectedtoanoxia-reoxygenation.Meth0ds:BMSCs/GDNFinducedintoneural-likecellswereCO— culturedwithneuronssubjectedtoanoxia-reoxygenation.Hoechst33258stainingwasusedtodetectapoptosisof ...
GFP标记的重组腺病毒GDNF基因在脑缺血大鼠脑内的表达
GeneID2668 SourceEscherichia coli. Molecular WeightApproximately 30.1 kDa, a homodimeric protein consisting of two 134 amino acid non-glycosylated polypeptide chains. Quantity2μg/10μg/1000μg AA SequenceSPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD ...
目的 观察NGF GDNF基因修饰神经干细胞 (NGF NSC和GDNF NSC)在AD模型鼠脑内的存活、分化及基因产物的表达。 方法 将BrdU标记的NGF NSC和GDNF NSC单独和联合移植入穹窿海马伞切断的大鼠侧脑室内。移植后 3周 ,用免疫组织化学方法对脑切片进行BrdU、Nestin、GFAP、NF、NGF及GDNF单标或双标染色。 结果 脑室内见到...