Expression of α2, 8-sialyltranferase (GD3 synthase) gene in human cancer cell lines: high level expression in melanomas and up-regulation in activated T lymphocytes - Yamashiro, Okada, et al. - 1995Yamashiro S, Okada M, Haraguchi M, Furukawa K, Lloyd KO, Shiku H, Furukawa K. ...
Disialoganglioside (GD3) Synthase Gene Expression Suppresses Vascular Smooth Muscle Cell Responses via the Inhibition of ERK1/2 Phosphorylation, Cell Cycle... CH.Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 ...
T. Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs Trimerization of the Fas receptor (CD95, APO-1), a membrane bound protein, triggers cell death by apoptosis. The main death pathway activated by Fas recept... O Micheau - 《Journal of ...
NF-κB was activated in HepG2 cells shortly after therapeutic doses of ionizing radiation or daunorubicin treatment that translated into up-regulation of κB-dependent genes. These effects were accompanied by minimal killing of HepG2 cells by either ionizing radiation or daunorubicin. However, GD3 ...
and activated kinase Yes colocalized in GEMs, promoting proliferation, invasion and a malignant phenotype.117In MDA-MB-231 breast cancer cells, the expression of GD3S induced the accumulation of b- and c-Series gangliosides including GD3, GD2, and GT3.118,119Among these complex gangliosides, GD...
1) and includes the production of activated monosaccharide building blocks by the epimerase Uge35,7 followed by synthesis and export by the predicted integral membrane glycosyltransferase Gtb35. The GAG cluster also encodes two glycoside hydrolases: an endo-α-1,4-N-acetylgalactosaminidase, Sph36,...
3.14. Gene Expression Assay To verify the expression of apoptotic and antiapoptotic genes at mRNA level in the samples exposed in HT29 cell line using quantitative real-time PCR (Figure 16), our data demonstrated that mRNA level of Bax was significantly upregulated while the expression of antiapo...
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-尾1-mediated anchorage. International Journal of Biochemistry and Cell... C Mandal,S Sarkar,U Chatterjee,... - 《International ...
Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: expression on human T cells with transendothelial m... with cDNA for GD3 synthase.The 6C2 molecule is a disialoganglioside, GD3, and is present on a subset of T cells with transendothelial mi...
The above antibody and its F(ab')2 segment polyvalently binds to T-lymphocytes whereby GD3 positive cell groups are activated, induce the production of IL-2, the expression of IL-2 receptor and cell proliferation. These actions are enhanced by exogenous IL-2, protein A, phorbol myristate ...