Human melanoma cell lines defi- cient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics. J Invest Dermatol 1996; 107: 543-8.Nakano J, Raj BKM, Asagami C, Lloyd KO (1996) Human melanoma cell lines deficient in GD3 ganglioside expression exhibit altered growth and...
Combing with Cibersort approaches, C3 was distinguished by significant immune cell infiltration, including activated CD4+ and CD8+ T cells, effector NK cells, and Th1 cells. Moreover, coactivation and checkpoint molecules were also highly expressed in C3 (Fig. 1C, Fig. S1D). Thus, we ...
and activated kinase Yes colocalized in GEMs, promoting proliferation, invasion and a malignant phenotype.117In MDA-MB-231 breast cancer cells, the expression of GD3S induced the accumulation of b- and c-Series gangliosides including GD3, GD2, and GT3.118,119Among these complex gangliosides, GD...
There are a number of studies indicating that integrin expression is up-regulated during malignant transformation, and integrin-mediated signals consisting of FAK, integrin-linked kinase (ILK), and ERK/MAPK, which determine cell fates such as cell growth and invasion, are activated in melanomas (...
1) and includes the production of activated monosaccharide building blocks by the epimerase Uge35,7 followed by synthesis and export by the predicted integral membrane glycosyltransferase Gtb35. The GAG cluster also encodes two glycoside hydrolases: an endo-α-1,4-N-acetylgalactosaminidase, Sph36,...
Homma T, Hosono O, Iwata S, Ando S, Sasaki K, Nishi T, et al. Morimoto, recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: expression on human T cells with transendothelial migratory activity. Arthritis Rheum 2001; 44: 296-306....
Study the expression of Neogene TIGD3 that derived from DNA transposons in colorectal cancer cell linesQasim, Ahmed H.AL-yarmouk Journall
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-尾1-mediated anchorage. International Journal of Biochemistry and Cell Biol- ogy 53, 162-173....
This increase occurred between 1 and 2 h post-incubation, preceding the onset of cell death by TNF. Furthermore, TNF activated both NSMase and ASMase within 20 min after TNF exposure (not shown). Download: Download full-size image Fig. 1. Susceptibility of HT-29 cells to TNF. HT-29 ...
Aim: The expression of Neogene TIGD3 in colorectal cancer cell lines and its putative function in carcinogenesis are being investigated. Method: The protein expression of the TIGD3 gene was investigated using the western blot method in twelve colorectal cancer cell lines (HCT116...