科学家还尝试使用体外扩增的具有抗GD2抗体的NK细胞来治疗神母患者,并且产生了一些治疗效果。此外,贝勒医学院的研究人员还开发了抗GD2的CAR-NKT细胞并且显示出初步的疗效。鉴于肿瘤细胞可以通过表达CD47来抑制巨噬细胞对于肿瘤细胞的吞噬作用,因此研...
最新研究显示，GD2 CAR-T细胞疗法在治疗神经母细胞瘤儿童患者中显示出积极的临床抗肿瘤活性和良好的耐受性。靶向GD2的CAR-NKT细胞疗法在贝勒医学院I期临床中期结果显示，安全性良好，可定位到肿瘤部位，1例患者获得客观缓解，骨转移病灶消退。
值得一提的是,百济神州从EUSA Pharma引进了Qarziba(迪妥昔单抗),2020年11月4日,百济神州向中国药监局提交了上市申请。 除了GD2靶向抗体药物之外,目前也有多家机构/公司正在开发GD2靶向的CAR细胞疗法,例如CAR-T/CAR-NKT等。 2020年11月...
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas Robbie G. Majzner, Sneha Ramakrishna, Kristen W. Yeom, Shabnum Patel, Harshini Chinnasamy, Liora M. Schultz, Rebecca M. Richards, Li Jiang, Valentin Barsan, Rebecca Mancusi, Anna C. Geraghty, Zinaida Good,...
et al. Adoptive transfer of invariant NKT cells as immunotherapy for advanced melanoma: a phase 1 clinical trial. Clin. Cancer Res. 23, 3510–3519 (2017). Article CAS PubMed PubMed Central Google Scholar Heczey, A. et al. Anti-GD2 CAR-NKT cells in patients with relapsed or refractory...
2020年11月25日,Science Translational Medicine期刊在线发表了一份来自英国研究团队的研究文章,文章中展示了12例神经母细胞瘤儿童患者在接受了GD2 CAR-T细胞治疗后,显示出积极的临床抗肿瘤活性但未达到客观的临床反应,并且耐受性良好。 2020年10月12日,Nature Medicine在线发表了贝勒医学院领衔团队靶向GD2的CAR-NKT治疗...
GD2 specific CAR and interleukin-15 expressing autologous NKT cells to treat children with neuroblastoma (GINAKIT2). ClinicalTrials.gov. Updated January 15, 2021. Accessed May 14, 2021.https://clinicaltrials.gov/ct2/show/NCT03294954 Related Videos ...
2020年10月12日,Nature Medicine在线发表了贝勒医学院领衔团队靶向GD2的CAR-NKT治疗复发难治性B细胞恶性肿瘤的I期临床中期结果。结果显示,靶向GD2的CAR-NKT细胞安全性良好,可定位到肿瘤部位;3例接受治疗的患者中有1例患者获得客观缓解,骨转移病灶消退。 参考资料: 1.biospace.com/article/re发布...
* To determine the activity of study treatments chosen based on: * How each subject responds to the study treatment A Phase 1, Two-Part, Multicenter, Open-Label First in Human Study of Anti-GD2 Antibody Drug Conjugate M3554 in Participants With Advanced Solid Tumors ...
CAR-NKT cells expanded in vivo, localized to tumors and, in one patient, induced an objective response with regression of bone metastatic lesions. These initial results suggest that CAR-NKT cells can be expanded to clinical scale and safely applied to treat patients with cancer....