*供应Gd-HP-DO3A/Gd-EOB-DTPA/Gd-BOPTA/Albumine-Gd-DTPA 西安齐岳生物科技有限公司是国内*的大环配体供应商;齐岳生物有自己的实验室和技术人才;*研发金属离子开发大环配体及其作为MRI造影剂;DOTA-mono-NHS-tris(t-Bu ester);Gd-DOTA-ACL;Maleimido-mono-amide-DOTA-tris (t-Bu ester);Ga-DOTA-多肽;Malei...
[Gd(HP-DO3A)] (gadoteridol) as an active compound of ProHance is a widely employed contrast agent in clinical MRI scans in the last 30years. Recent concerns about the long-term retention of gadolinium-based contrast agents (GBCAs) led to a deeper investigation of the...
Temperature-sensitive liposomes (TSLs) loaded with doxorubicin (Dox), and Magnetic Resonance Imaging contrast agents (CAs), either manganese (Mn2 +) or [Gd(HPDO3A)(H2O)], provide the advantage of drug delivery under MR image guidance. Encapsulated MRI CAs have low longitudinal relaxivity (r1)...
Runge VM, Gelblum DY, Jacobson S: Gd HP-D03A —Experimental evaluation in brain and renal MR. Magnetic Resonance Imaging 9: 79–87, 1991Runge VM, Gelblum DY, Jacobson S. Gd HP-DO3A--Experimental evaluation in brain and renal MR. Magnetic Resonance Imaging 1991;9(1):79-87....
We report that in GdHPDO3A-like complexes a primary amide group located in close proximity to the coordinated hydroxyl group can provide a strong relaxivity enhancement at slightly acidic pH. A maximum relaxivity of r1 = 9.8 mM1 s1 (20 MHz, 298 K) at acidic pH was achieved, which is ...
Thus, four new Gd(III) complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) macrocyclic structure were designed and synthesized by introducing further polar and protic functional groups (amides, phosphonates, and diols) adjacent to ...
MRI contrast agentsrelaxometryThe properties of Ln(III)〩PDO3A complexes as relaxation enhancers and paraCEST agents are essentially related to the hydroxylpropyl moiety. A series of three HPDO3A derivatives, with small modifications to the hydroxyl arm, were herein investigated to understand how ...
Yeo SY, de Smet M, Langereis S, Vander Elst L, Muller RN, Grull H. Temperature-sensitive paramagnetic liposomes for image-guided drug delivery: Mn 2 versus [Gd (HPDO3A)(H 2 O)]. Biochim Biophys Acta 2014;1838:2807-2816.S.Y. Yeo, M. de Smet, S. Langereis, L. Vander Elst, R...
Muller, H. Grull, Temperature- sensitive paramagnetic liposomes for image-guided drug delivery: Mn(2+) versus [Gd(HPDO3A)(H2O)], Biochim. Biophys. Acta 1838 (2014) 2807-2816.Yeo SY, de Smet M, Langereis S, Vander Elst L, Muller RN, Grull H. Temperature-sensitive ...
Temperature-sensitive liposomes (TSLs) loaded with doxorubicin (Dox), and Magnetic Resonance Imaging contrast agents (CAs), either manganese (Mn2 +) or [Gd(HPDO3A)(H2O)], provide the advantage of drug delivery under MR image guidance. Encapsulated MRI CAs have low longitudinal relaxivity (r1...