Targeting GCN5-mediated K525 Kcr of DNA-PKcs may be a promising therapeutic strategy for improving the outcome of cancer radiotherapy.doi:10.1038/s41416-024-02636-4Han, YangDept Radiat BiolZhao, HonglingUniversity of South ChinaLi, GangJia, JinGuo, HejiangTan, JinpengSun, XingyaoLi, SaiyuRan...
GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity Yang Han Hongling Zhao Ping-Kun Zhou British Journal of Cancer (2024) Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth Namin...
Cells were stained with the DNA dye bisbenzimide (Hoechst 33258; 5 μg/ml) to determine the infectious efficiency of the two adenovirus by scoring the rate of GFP-positive neurons in all cells in the same visual field. DNA fragmentation analysis (DNA ladder) Cells were lysed in TE ...
DNA damage responseEpigeneticsBrain tumorRadio-sensitizationGlioblastomaGCN5PARP1PARylationDNA-PKcsAcetylationEfficient DNA double strand break (DSB) repair is necessary for genomic stability and determines efficacy of DNA damaging cancer therapeutics. Spatiotemporal dynamics and post-translational modifications of...
3D). Furthermore, a low resolution crystal structure of another phosphatidylinositol 3-kinase-related kinase protein, DNA-PKcs, shows a globular region with slender projections that form a ring (32), reminiscent of the arrangement of electron density within the SAGA head. Although our three-...