Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the...
In the GCKKI/- liver, there were no changes in the morphology, but glycogen content was reduced. The level of plasma HDL significantly increased, plasma TC and LDL levels decreased, and TG levels did not change.SHUHUI JIHUA SHUWENLI FENG...
Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism.The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Moreover, GCK has been found to have relationship with diabetes. ...
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA, Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1...
Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism.The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Moreover, GCK has been found to have relationship with diabetes. ...
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the...
Positive samples LO2, A-549, mouse liver, rat liver Cellular location Cytoplasm, Nucleus Customer validation - About the Immunogen Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 250-465 of human GCK (NP_000153.1). Sequence RMCVNTEWGAFGDSGELDEFLLEYDRLV...
Gene SummaryHexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein local...
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to th...
and body weight were recorded. The mice were sacrificed at the end of the experiment. The plasma levels of ALT, AST, TC and TG were detected by automatic biochemical analyzer. The liver was prepared by paraffin section and stained by HE staining kit. The RNA was extracted from the liver ...