当机体受到损伤或炎症侵害时,受GCH1基因编码的GCH1数量在神经元中上调,随后GCH1蛋白和BH4的合成也上调。 体外细胞实验显示,不同细胞培养条件下,使用促炎症因子,脂多糖等因子作用于细胞可使GCH1基因上调;实验中发现一种GCH1单倍体,这种单倍体可有效降低人对疼痛的敏感性,使痛觉下降。这可能是因为GCH1单倍体使GCH...
Latremoliere A, Costigan M: GCH1, BH4 and pain. Curr Pharm Biotechnol 2011. Current review on the link between BH4 and pain.Latremoliere A, Costigan M. GCH1, BH4 and pain. Curr Pharm Biotechnol 2011 ; 12 : 1728-41.Latremoliere, A., and Costigan, M. (2011). GCH1, BH4 and ...
尽管中性粒细胞和巨噬细胞在GCH1+白细胞中占比较大,但肥大细胞中的GCH1表达水平最高。多光子成像显示,术后肥大细胞与感觉神经末梢之间存在稳定的相互作用,表明肥大细胞可能通过释放BH4和血清素参与术后疼痛的调节。 研究还发现,肥大细胞特异性GCH1缺失小鼠表现出机械性和热性疼痛敏感性的显著降低,并伴随着足部BH4和...
1:辐射减少GCH1与BH4的表达水平导致皮肤组织NO稳态失衡 NOS的稳定对皮肤稳态至关重要,而BH4为NOS的辅助因子,且BH4易被活性氧氧化为BH2。为了检测辐射是否对BH4水平有影响,作者检测了辐照前后HaCat细胞与WS1细胞的细胞提取物中紫外-可见光吸收光谱(图...
本文对GCH1基因及BH4与疼痛的关系进行综述。图片来源于网络 1.疼痛发病机制 疼痛是由痛觉感受器、神经纤维及痛觉中枢共同参与的防御性机制。当机体受到疼痛刺激或受到伤害时,局部组织会直接释放一些物质(如组胺、缓激肽及钾离子等物质),使疼痛阈值下降。疼痛进一步经分布在皮肤、关节、内脏、神经及肌肉等的感受器通过...
GCH1基因、BH4对疼痛的作用机制研究进展(4) 循环途径即是当机体SPR缺乏时候,GCH1将GTP转化为7,8-二氢蝶呤三磷酸,再通过PTS在醛糖还原酶和羰基还原酶催化反应下形成BH2,然后通过二氢叶酸还原酶将其转化为BH4。补救途径即是指醌类-二氢生物喋呤在醌类-二氢生物蝶呤还原酶的作用下,最终将其转化为BH4。同时,...
We explain the nature of the GCH1 reduced-function haplotype and set out the potential for a ‘BH4 blocking’ drug as a novel analgesic.Alban LatremoliereMichael CostiganotherLatremoliere A, Costigan M. GCH1, BH4 and pain. Curr Pharm Biotechnol 2011: 12: 1728-1741....
检测四氢生物喋呤(BH4)含量.结果 4周后,A-TP组较对照组GCH1表达明显下降(P〈0.05).与对照组相比,GCH1过表达组心房有效不应期明显延长,RSFP中PGP9.5表达下降明显,BH4含量增加.与对照组相比,GCH1沉默组RSFP中PGP9.5表达明显上升,BH4含量减少.结论右房快速起搏导致GCH1基因表达下调,GCH1可能通过增加BH4含量抑制房颤...
Overexpression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme for BH4 synthesis, restored cellular BH4 levels and NO production and decreased radiation-induced ROS. GCH1 also protected skin cells and rat skins against radiation-induced damage. We found that GCH1 was regulated by NF-E2...
This study demonstrates that the risk of NSCL/P is associated with variants of the GCH1 gene related to BH4 metabolism and provides some evidence of the relationships between morphological/functional shifts in the central nervous system and orofacial clefts....