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In general, the use of floating systems comes with certain potential issues. These include the possibility that system units may stick together (for multiple-unit systems) or be obstructed in the GIT, which could cause gastric irritation. Therefore, drugs that may have an irritating effect on ...
2.8. Cell Culture The Caco-2 human intestine cell line obtained from Sigma Aldrich Canada was cultured in high-glucose Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum and 1% penicillin–streptomycin. The cells were incubated under a 5% CO2 atmosphe...