Lauren classificationMucin phenotype expressionCancer stem cellGastric cancer (GC), one of the most common human cancers, is a heterogeneous disease with different phenotypes, prognoses, and responses to treatment. Understanding the pathogenesis of GC at the molecular level is important for prognosis ...
classificationofgastriccarcinomahasbeenlargelybased onLauren'scriteria,inwhichgastriccancerisclassiedinto twomajorhistologicalsubtypes,namelyintestinaltypeand diffusetypeadenocarcinoma.Thisclassicationwasintroduced in1965,andremainscurrentlywidelyacceptedandemployed, ...
Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. The role of the microorganisms in gastric tumorigenesis attracts much attention in recent years. These microorganisms include bacteria, virus, and fungi. Among them,Helicobacter pylori(H. pylori) infection is by f...
Pathological classification According to the World Health Organization guidelines, GC can be classified as adenocarcinoma, signet ring-cell carci- noma, and undifferentiated carcinoma. However, it is not as widely used as the Lauren classification, which distinguishes two major subtypes of GC, ...
The aim of the current review is to analyze the two major histological subtypes of gastric cancer, as proposed by the Lauren classification, and to discuss the implications of this for personalized chemotherapy. 展开 关键词: gastric cancer Lauren classification intestinal type diffuse type ...
Cancer 97, 3133–3275 (2003). Article PubMed Google Scholar Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand. 64, 31–49 (1965). Article CAS Pub...
The Lauren classification recognizes two major types of gastric carcinomas, the "intestinal" and the "diffuse," which display different clinicopathological characteristics and occur in different epidemiologic settings. Microscopically, the "intestinal" type gastric carcinoma retains a glandular structure and ...
Using Lauren classification, immunoreactivity was positive for p53 in 62.5% of thecases: 7 cases of well differentiated intestinal low index gastric carcinoma, 1 case of poorly differentiated intestinal low tomoderate index gastric carcinoma, 15 cases of diffuse moderate to high index gastric carcinoma...
Gastric cancer: classification, histology and application of molecular pathology. J. Gastrointest. Oncol. 3, 251–261 (2012). PubMed PubMed Central Google Scholar Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a ...
2, 3 Gastric cancer is histologically divided into two types in the Lauren classification: intestinal (with intercellular junctions) and diffuse (without intercellular junctions).4 More than 90% of gastric cancers are intestinal-type adenocarcinoma, which is believed to be preceded by a “precancer...