The Gas6/TAM (Tyro3, Axl, and Mer) receptor system has been implicated in demyelination and delayed remyelination in experimental animal models, but data in humans are scarce. We aimed to investigate the role of Gas6/TAM in neurodegenerative processes in multiple sclerosis (MS).From a ...
In conclusion, Gas6 receptors are not equally important in platelet activation, Axl and Tyro3 play more critical role than Mer in GPVI-mediated platelet activation. The trans-interaction of Axl or Tyro3 mediates cell-cell contact-dependent activation, which facilitates the activation of GPVI in ...
Expression of Gas6 and Mertk mRNA was detectable in oocytes and follicular cells, while Tyro3 and Axl mRNA was expressed only in follicular cells. Expression of Mertk mRNA was relatively constant during oocytes maturation and embryogenesis, but the other receptors, Tyro3 and Axl, were not ...
GAS6oligodendrocytesremyelinationTAM receptorsTYRO3vitamin KMultiple sclerosis is an autoimmune disease of the central nervous system (CNS) characterized by demyelination, axonal damage and, for the majority of people, a decline in neurological function in the long-term. Remyelination could assist in ...
Role of Tyro3, Axl, and Mer Receptors and Their Ligands (Gas6, and Protein S) in Patients with Hepatocellular Carcinoma. J. Cancer Ther. 2017, 8. [CrossRef]Uehara, S.; Fukuzawa, Y.; Matuyama, T.; Gotoh, K. Role of Tyro3, Axl, and Mer Receptors and Their Ligands (Gas6, and ...
Gas6, expressed ubiquitously in bone cells, did not affect the differentiation or the survival of osteoclasts, but stimulated osteoclast function to form resorbed pits on a dentine slice. The expression of its receptor, Tyro 3, was seen only in mature osteoclasts among bone cells. Gas6 up-...
Immunoexpression of Tyro 3 family receptors — Tyro 3, Axl, and Mer — and their ligand Gas6 in postnatal developing mouse testis. J Histochem Cytochem. 2005; 53 (11):1355–1364. doi: 10.1369/jhc.5A6637.2005. [ Cross Ref ]Wang H, Chen Y, Ge Y, Ma P, Ma Q, Ma J, Wang H, ...
Gas6 inhibits the decrease in BACE1 protein level induced by Tyro3 overexpression in 293APPswe cells.Yan ZhengQi WangBing XiaoQingjun LuYizheng WangXiaomin Wang
et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80, 661-670 (1995).Stitt, T.N., Conn, G., Gore, M., Lai, C., Bruno, J., Radziejewski, C., Mattsson, K., Fisher, J., Gies, D....
TAM receptors and Gas6 ligand levels did not correlated with disease activity parameters. JIA patients had soluble levels similar to healthy controls. ( Table ) T1 Table 1. Soluble Tyro3, Axl, Mer and Gas6 ligand levels in sera from patients with JSLE, JIA and healthy individuals. Mean ±...