a, Presence of GAP43+MT-like connections (arrows) between mitoDsRed+astrocytes and P3 tumor cells. Immunostaining for GAP43 (white) and actin (green) is shown. Left: mitoDsRed (red), GAP43 and actin. Middle: mitoDsRed and actin. Right: mitoDsRed and GAP43. Images are representative ...
Binding to actin filaments may also assist in restricting the protein to specific cellular domains. Consistent with its role as a plasticity protein," there is evidence that GAP‐43 can directly alter cell shape and neurite extension, and several theses have been advanced for how it might do ...
GAP-34对于长期增强的磷酸化反应说明该蛋白在神经元的突触可塑性中起作用。该磷酸化反应的催化剂为蛋白激酶C。GAP-43也是生长锥体膜复合物一种主要的蛋白,它的表达与有效的中枢神经系统再生相关,还与哺乳动物的外周神经再生相关(Neve,R.L.,Perrone-Bizzozero,N.I.,Finklestein,S.,Zwiers,H.,Bird,E.,Kurnit,D...
filamentous actin GAP: growth‐associated protein GAP‐43: growth‐associated protein‐43 kb: kilobase LTP: long‐term potentiation mRNA: messenger ribonucleic acid N‐CAM: neuronal cell adhesion molecule NMDA: N‐methyl‐d‐aspartate PC12: pheochromocytoma cell line PFC: prefrontal cort...
Western blot analysis of extracts from various tissues and cell lines using GAP43 (E1U1D) Mouse mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Negative expression of GAP43 protein in MBT2 cells is consistent with the predicted expression pattern. Data were generated us...
GAP-43 has been shown to play an important role in neuronal pathfinding, particularly in sites where axons must choose between two almost identical paths1.The presence of GAP-43 in growing cells influences the behavior of those cells, perhaps by affecting the behavior of the actin cytoskeleton;...
5QinH,DentEW,MeiriKF.Modulationofactinfilamentbehaviorby GAP 一43(neuromodulin)isdependentonthephosphorylationstatus ofSet4l,theProteinKinaseCsite.JNeurosci,1997,17(10): 35l5. 6CapriniM.GomisA.CabedoH.eta1.GAP 一43stimulatesinositol trisphosphate—mediatedcalciumreleaseinresponsetohypotonicity. ...
Growth-associated protein-43 (GAP-43) is a major nervous system protein whose phosphorylation by protein kinase C regulates growth cone responses to extracellular guidance cues via F-actin. GAP-43 is essential for axon pathfinding in both cortical afferents and efferents: when it is genetically del...
C, representative Western blot analysis of GAP-43, syntaxin I (STX-I), PSD-95, and actin expression in extracts prepared from whole-brain extracts (WBE) and presynaptic terminals (Pre.). D and E, representative Western blot analysis (D) and normalized integrated intensity of the band (E)...
Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Database Links: Entrez Gene: 9474 ...