GaoBinge模型在酒精性肝病研究领域应用现状及未来前景
关键词:肝疾病,酒精性;模型,动物;Gao—Binge模型中图分类号:R575 文献标志码:A 文章编号:1001—5256(2019)03—0485—04Application status and future prospect of the Gao—-Binge model in alcoholic liver diseaseZHOU Ke,WANG Hua.(School of Pharmacy,Institute of Liver Diseases,Anhui Medical University,...
26, No. 5, October 30, 2013慢性酒精喂养加急性酒精灌胃的酒精性肝病小鼠模型 ( NIAAA 模型或 Gao-Binge 模型 )高斌,常彬霞,徐明江[摘要] 酒精性肝病是进展期肝病非常重要的原因之一,目前对其发病机制及治疗靶点的研究主要基于动物模型,因此建立一个与人类酒精性肝病类似的模型就至关重要。过去建立的一些酒精性...
Hepatocyte-specific HIF-1β knockout mice were resistant to steatosis and liver injury from the Gao binge model.HongMin NiAmar BhaktaShaogui WangZhenrui LiSharon ManleyHeqing HuangBryan CoppleWenXing Ding
Role of Hypoxia Inducing Factor-1β in Alcohol-Induced Autophagy, Steatosis and Liver Injury in Mice We further found that hepatocyte-specific HIF-1 knockout mice developed less steatosis and liver injury following the Gao-binge model or acute ethanol treatment compared with their matched wild type...
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reported. This model induces significant steatosis, hepatic neutro-phil infiltration, and liver injury. A clinically relevant model of high-fat diet feeding plus binge ethanol was also developed, which highlights the risk of excessive binge drinking in obese/overweight individuals. All of these model...
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Good morning, my dear teachers and friends! My name is Li Binge, from class four O five. Today, I am very happy to be here. My topic is “Our School”. My dear friends, welcome to our school! My school is very beautiful! It has a big playground. We can play and do some sports...