In this study, the SARS-CoV-2 main protease (M pro ) was selected as the drug target. Two distinct GAN algorithms were employed to generate novel small molecules. One approach utilized experimental electron density (ED-based) data of ligands for training to generate drug-like molecules, while...
该生成模型利用转录组学数据进行训练,这样可高概率地自动生成所需转录组谱的分子,在只提供所需状态的基因表达标记而无需对任何训练的化合物进行提前靶标注释的情况下,该模型就能自动为所需靶标设计类似活性的分子,并且得到了与活性化合物更相似的分子,这为药物研发提供了一种新的方法。 1 背景 药物研发是一个漫长...
005 (2020-06-12) Dynamic Attention Based Generative Adversarial Network with Phase Post-Processing for Speech Enhancementhttps://arxiv.org/pdf/2006.07530.pdf 006 (2020-06-12) Defending against GAN-based Deepfake Attacks via Transformation-aware Adversarial Faceshttps://arxiv.org/pdf/2006.07421.pdf ...
The LC–MS-based metabolomic approach is a powerful, effective and unbiased tool for profiling of drug metabolism and bioactivation. L Feng,FJ Gonzalez,X Ma - 《Acta Pharmaceutica Sinica B》 被引量: 7发表: 2012年 Optical energy switching device and method An optical power or energy-switching ...
006 (2020-06-26) HypervolGAN An efficient approach for GAN with multi-objective training function https://arxiv.org/pdf/2006.15228.pdf 007 (2020-06-25) Lesion Mask-based Simultaneous Synthesis of Anatomic and MolecularMR Images using a GAN ...
A network pharmacology-based approach to explore potential targets of Caesalpinia pulcherima: an updated prototype in drug discovery Article Open access 14 October 2020 Introduction Bronchial asthma (hereinafter referred to as asthma) is the most common chronic respiratory disease in the world1. It ...
002 (2023-07-6) A Privacy-Preserving Walk in the Latent Space of Generative Models for Medical Applications https://arxiv.org/pdf/2307.02984.pdf 003 (2023-07-5) DeSRA Detect and Delete the Artifacts of GAN-based Real-World Super-Resolution Models ...
A dose-escalation approach was used, whereby preliminary safety, tolerability and PK data from the previous cohort were reviewed by the Dose Escalation Committee before selecting the next cohort dose; efficacy data were also considered, if available. Dose escalation was based on population PK modeling...
097 (2023-08-7) Energy-Guided Diffusion Model for CBCT-to-CT Synthesis arxiv.org/pdf/2308.0335 098 (2023-08-6) Photorealistic and Identity-Preserving Image-Based Emotion Manipulation with Latent Diffusion Models arxiv.org/pdf/2308.0318 099 (2023-08-16) Generative Approach for Probabilistic Human...
Deep generative design of RNA family sequences Article 18 January 2024 Transformer-based protein generation with regularized latent space optimization Article 26 September 2022 Data availability Demo, instructions and code for FBGAN are available at https://github.com/av1659/fbgan. All of the dat...