This chapter discusses the purification and characterization of γ-tubulin ring complex (γTuRC) and γ-tubulin small complex (γTuSC) and the function of γTuRC at the centrosome. The proposed mechanism of γT
Two types of gamma-tubulin complexes are found in eukaryotes: a small complex, also named “gamma-TuSC” for “gamma-tubulin small complex,” and a large “gamma-tubulin ring complex,” also named “gamma-TuRC.”30Gamma-TuSCs contain a dimer of laterally associated GCP2 and GCP3 that are...
The gamma-tubulin (TUBG1; relative molecular weight about 48 kDa) is a minor member of tubulin family (less that 0.01% of tubulin dimer). The g-tubulin ring structures, however, serve to provide structural primer for initiation of microtubular nucleation and growth, thereby being crutial for ...
The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is...
Description tubulin gamma 1(TUBG1) Homo sapiens This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and...
The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is...
The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is...
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progress...
Core complex proteins are found associated with additional proteins (GCP4–GCP6) to form larger γ-tubulin ring complexes (Moritz et al., 1995, Zheng et al., 1995). In plants, high molecular weight soluble complexes containing γ-tubulin have been detected (Stoppin-Mellet et al., 2000), ...
Thecentrosomenucleates and anchors microtubules to organize a radial microtubule array duringinterphaseand to assist in bipolar spindle formation during mitosis (Figures 3(a) and (b)). Microtubule nucleation is promoted by a number of factors but the most important is the γ-tubulin ring complex (...