Gamma‐aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the vertebrate central nervous system, and it is intimately related to learning and memory. This study aims to evaluate whether altered cognitive behavior involves the GABA signaling pathway in male offspring of rats ...
Gamma-aminobutyric acid(GABA), a four-carbon non-proteinamino acid, is a significant component of the free amino acid pool in most prokaryotic and eukaryotic organisms. In plants, stress initiates a signal-transduction pathway, in which increased cytosolic Ca2+activates Ca2+/calmodulin-dependentglutam...
Interestingly, gamma-aminobutyric acid (GABA), a functional amino acid, has been involved in immune regulation as an effective immunomodulator [9]. Researchers have also found the distribution of GABA in immunocytes (e.g. T lymphocytes) and the extracellular space [10,11]. Furthermore, GABA ...
γ-taVNS elicits microglial phagocytosis and regulates microglial pyroptosis by effectively suppressing the P2 × 7R/NLRP3/caspase-1 pathway in the hippocampus [124]. Additionally, γ-taVNS exerts inhibitory effects on the hippocampal NF-κB ...
GABA (Gamma-aminobutyric acid), a crucial neurotransmitter in the central nervous system, has gained significant attention in recent years due to its extensive benefits for human health. The review focused on recent advances in the biosynthesis and produ
Gamma-aminobutyric acid (GABA), a ubiquitous non-protein 4-carbon amino acid present in both prokaryotic and eukaryotic organisms. It is conventionally rec
In plants, GABA plays a critical role in regulating salinity stress tolerance. However, the response of soybean seedlings (Glycine max L.) to exogenous gamma-aminobutyric acid (GABA) under saline stress conditions has not been fully elucidated. This stud
Metabolic and neuroactive metabolite production represents one of the mechanisms through which the gut microbiota can impact health. One such metabolite, gamma-aminobutyric acid (GABA), can modulate glucose homeostasis and alter behavioural patterns in t
SSADH is responsible for the second step on the degradation of the gamma-aminobutyric acid (GABA) pathway, converting succinate semialdehyde (SSA) into succinate, a TCA intermediary [102]. Additionally, sunitinib upregulated eight proteins [67,71,72], including P5CDH [71], mitochondrial branched-...
Our metabolomic analyses reveal that gamma-aminobutyric acid (GABA) levels are increased in the interscapular BAT of mice with dietary obesity. We also found a significant increase in GABA-type B receptor subunit 1 (GABA-BR1) in the cell membranes of brown adipocytes of dietary obese mice. ...