Gamma-aminobutyric acid (GABA) analogues for the treatment of pain and other disordersEquation (1) Embedded image , Wherein RRepresents hydrogen, halo, C1-C4 alkyl, C1-C4 alkyl halide, C1-C4 alkoxy-C2-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl or C3-C7 cycloalkyl; R(1) 'or Formula (1...
γ-Aminobutyric acid analogues γ-Aminobutyric acid (GABA) is the chief inhibitoryneurotransmitterin the central nervous system. It can bind to two kinds ofGABA receptors: GABAAand GABAB. GABA analogues act asallosteric modulatorsof GABA receptors. Usually, this kind of molecule has relaxing and ant...
Using the molecular orbital methods, we examined molecular structure, electron density distribution, electrostatic potential field and receptor structure of gamma-aminobutyric acid (GABA), and its analogues. The following findings were obtained: a comparison of the biological activity and the morphology ...
gamma-Aminobutyric acid (GABA), a flexible achiral neurotransmitter, acts at different subclasses of receptors and participates in transport processes. Conformationally restricted GABA analogues exert selective biological effects. Besides fulfilling conformational recognition by different binding sites of receptors...
Title: Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Authors: Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Fu...
Antiseizure Activity of Novel 纬-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogues in Mice and Rat Models Sieghart W, Cook JM: Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. ... Feli...
but there was a perception among legislators that all known analogues should be covered as far as this was possible. Attempts to circumvent the illegal status of GHB have led to the sale of derivatives such as 4-methyl-GHB (gamma-hydroxyvaleric acid, GHV) and its prodrug form gamma-valerola...
Gamma-hydroxybutyric acid (GHB), a naturally occurring short-chain fatty acid related to gamma-aminobutyric acid (GABA), rapidly produces effects that have been likened to a combination of alcohol (euphoria, reduced anxiety, drowsiness, loss of motor control) and ecstasy (enhanced sensuality, emotio...
Dipropylacetic acid (DPA), and anticonvulsant known to raise brain gamma-aminobutyric acid (GABA), was administered orally to eight patients with Huntingto... I Shoulson,R Kartzinel,TN Chase - 《Neurology》 被引量: 248发表: 1976年 A new class of conformationally rigid analogues of 4-amino...
they play a role in virtually all brain functions. The endogenous ligand of the GABAAR is gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. GABAARs are heteropentameric, ligand-gated ion channels. Nineteen GABAAreceptor subunits have been identified ...