Gamma-aminobutyric acid (GABA) analogues for the treatment of pain and other disordersEquation (1) Embedded image , Wherein RRepresents hydrogen, halo, C1-C4 alkyl, C1-C4 alkyl halide, C1-C4 alkoxy-C2-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl or C3-C7 cycloalkyl; R(1) 'or Formula (1...
γ-Aminobutyric acid analogues γ-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the central nervous system. It can bind to two kinds of GABA receptors: GABAAand GABAB. GABA analogues act as allosteric modulators of GABA receptors. Usually, this kind of molecule has relaxing...
but there was a perception among legislators that all known analogues should be covered as far as this was possible. Attempts to circumvent the illegal status of GHB have led to the sale of derivatives such as 4-methyl-GHB (gamma-hydroxyvaleric acid, GHV) and its prodrug form gamma-valerola...
Gamma-hydroxybutyric acid (GHB), a naturally occurring short-chain fatty acid related to gamma-aminobutyric acid (GABA), rapidly produces effects that have been likened to a combination of alcohol (euphoria, reduced anxiety, drowsiness, loss of motor control) and ecstasy (enhanced sensuality, emotio...
A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of gamma-aminobutyric acid aminotransferase. Recently, we found (Qiu, J.; Pingsterhaus, J. M.; Silverman, R. B. J. Med. Chem. 1999, 42, 4725-4728) that conformationally rigid analogues ...
gamma-aminobutyric acid (GABA) A receptor, alpha 5, B966183, hypothetical protein FLJ12983, NM—024856.1, sialophorin (gpL115, leukosialin, CD43), J04536.1, cerebellar degeneration-related protein (34 kD), M16965.1, hydroxyacid oxidase 2 (long chain), hydroxy-delta-5-steroid dehydrogenase (...
EVIDENCE that (+)bicuculline (BIC) is a competitive antagonist of the central inhibitory transmitter gamma-aminobutyric acid (GABA) is based1 mainly on apparent similarities between the molecular structures of BIC, GABA and agonists of GABA. Until recently, there has not been any explanation of th...
gamma-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced i... Experimental and occupational exposure to Methyl Tert-Butyl Ether (MTBE) has been reported to induce neurotoxicological and neurobehaviora...
Abstract. Objective: γ-Hydroxybutyrate (GHB) has gained popularity as a drug of abuse. In the Netherlands the number of patients in treatment for GHB
Functional gamma-aminobutyric acid type B (GABA(B)) receptors are normally only observed upon coexpression of GABA(B1) with GABA(B2) subunits. A C-terminal... M Gassmann,C Haller,Y Stoll,... - 《Molecular Pharmacology》 被引量: 122发表: 2005年 The highly homologous isoschizomers RsrI ...