GalNAc CPG allows the synthesis of siRNA - GalNAc laced. N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.通过将其直接与寡核苷酸结合或将其修饰到特定的递送系统作为靶向部分，GalNAc在核酸疗法的发展中...
GalNAC CPG allows the synthesis of siRNA - GalNAC laced.N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.Directly by the combined with few nuclear wast, acid or the targeted delivery system as pa...
但由于ASGPR仅在肝实质细胞特异性高表达,存在组织局限性。 N - b of cool galactosamine (GalNAc) coupling modification is the most commonly used small nucleic acid drug delivery system. GalNAc is to sialic acid glycoprotein receptor (ASGPR) ligands, nM level high affinity to ASGPR, then under the ...
GalNAc偶联修饰是当前最常用的小核酸药物递送系统。GalNAc共轭技术的其他试剂可根据要求提供。 GalNAC CPG allows the synthesis of siRNA - GalNAC laced.N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.Direc...
●中文名:N-乙酰半乳糖胺 CPG ●英文:GalNAc CPG ●外观以及性质: GalNAc CPG 允许合成 siRNA-GalNAc 偶联物,N-乙酰半乳糖胺 (GalNAc) 是一种明确的肝脏靶向部分,得益于其与去唾液酸糖蛋白受体 (ASGPR) 的高…
CpG allows the synthesis of siRNA GalNAc conjugates, and N-acetylgalactosamine (GalNAc) is a well-defined liver targeting moiety, thanks to its high affinity for asialoglycoprotein receptor (ASGPR). GalNAc has achieved remarkable success in
GalNAc偶联修饰是当前最常用的小核酸药物递送系统。GalNAc共轭技术的其他试剂可根据要求提供。 GalNAC CPG allows the synthesis of siRNA - GalNAC laced.N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.Direc...
GalNAc-siRNA conjugates rely on the activity of ASGPR, which is the transmembrane lectin receptor highly expressed on hepatocytes. ASGPR that can effectively clear substrates from the blood via a a receptor-mediated endocytosis processes with broad application across species. Has high affinity for GalNA...
N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety benefiting from its high affinity with asialoglycoprotein receptor (ASGPR). By conjugating it directly to the oligonucleotides or decorating it to a certain delivery system as a targeting moiety, GalNAc has achieved compelling succ...
GalNAc conjugates– GalNAc, or N-acetylgalactosamine, is a sugar molecule that can recognize and bind to a cell surface protein, the asialoglycoprotein receptor (ASGPR), which is abundantly expressed on liver cells (hepatocytes). The binding affinity to the receptor increases exponentially if severa...