A large and highly water-exposed Sudlow site I allows high mobility of bound sugars. Nonetheless, more protein contacts imply a tighter binding of fructose than galactose. Although galactose and glucose are epimers, galactose forms a different interaction network which disrupts a formation of ...
The most common hexoses are glucose, galactose, mannose, and fructose. The first three are aldoses, whereas fructose is a ketose. Glucose, galactose and mannose are epimers in that they differ from one another at a single center of asymmetry. Thus, glucose is the 4-epimer of galactose becau...
Recognition of both sugar epimers is accomplished principally by hydrogen bonding of Asp14 OD1 with the equatorial OH4 of D-glucose and OD2 with the axial OH4 of D-galactose. These results are reconciled with equilibrium and fast kinetics data, which indicate binding of both anomers of the ...