4 and 5). In this scenario, the methyl keto moiety of pAcF, which cannot be provided by any proteinogenic amino acids, is essential for productive binding of the two aglycones. In natural product biosynthetic pathways, the order of enzymatic steps is usually fixed to prevent metabolic flux ...
but had a restricted distribution within theVibrionaceae. Interestingly, deletion ofeda1(VP0065), that encodes 2-keto-3-deoxy-6-phosphate-gluconate (KDPG) aldolase (EDA), a key enzyme in the Entner–Doudoroff (ED) pathway, did not inhibit...