function名— 功能名 · 作用名 · 性能名 · 函数名 · 机能名 · 功用名 · 官能名 function动— 活动动 · 运行动 of— 的 查看其他译文 © Linguee 词典, 2024 ▾ 外部资源(未审查的) [...]priority “Philosophical reflection and prospective and anticipatory studies” which would help fulfil ...
Define Gain of function. Gain of function synonyms, Gain of function pronunciation, Gain of function translation, English dictionary definition of Gain of function. n. 1. The act or process of being altered or changed. 2. An alteration or change, as in n
Recent studies, particularly those on influenza viruses, have led to renewed attention on DURC, as there is an ongoing debate over whether the benefits of gain-of-function (GOF) experiments that result in an increase in the transmission and/or pathogenicity of potential pandemic pathogens (PPPs...
摘要: Gain of function mutations describes mutations that result in new (protein) functions in heterozygous individuals. Huntington's DiseaseLoss of Function MutationMendelian Forms of Human Hypertension... DOI: 10.1007/3-540-29623-9_7112 被引量: 69 年份: 2005 收藏...
Similarly, loss and gain of MeCP2 function result in significant effects on neuronal plasticity, dendritic morphol- ogy, processes associated with short- and long-term plasticity, and in excitatory/inhibitory balance in neuro- transmission. It is striking that levels of MeCP2 appear to have a ...
as a result of one's efforts; obtain; secure: to gain possession of land; to gain permission to enter. 2. to acquire as an increase or addition: to gain weight; to gain speed. 3. to obtain as a profit or advantage: He didn't stand to gain much by the deal. 4. to win; get...
Similar to Arabidopsis thaliana, the wild soybeans (Glycine soja) and many cultivars exhibit indeterminate stem growth specified by the shoot identity gene Dt1, the functional counterpart of Arabidopsis TERMINAL FLOWER1 (TFL1). Mutations in TFL1 and Dt1 both result in the shoot apical meristem (...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...
While this process is not fully understood, it is believed that if these genes themselves mutate, the result can be a higher mutation rate of all genes in an organism. Induced Mutations Mutations may be induced by exposure to ultraviolet rays and alpha, beta, gamma, and X radiation, by ...
patient variant (p.Ser550Tyr) recapitulated aspects of the human disease that could be partially treated with a SYK inhibitor or transplantation of bone marrow from wild-type mice. Our studies demonstrate that SYK gain-of-function variants result in a potentially treatable form of inflammatory ...