function名— 功能名 · 作用名 · 性能名 · 函数名 · 机能名 · 功用名 · 官能名 function动— 活动动 · 运行动 of— 的 查看其他译文 © Linguee 词典, 2024 ▾ 外部资源(未审查的) [...]priority “Philosophical reflection and prospective and anticipatory studies” which would help fulfil ...
Define Gain of function. Gain of function synonyms, Gain of function pronunciation, Gain of function translation, English dictionary definition of Gain of function. n. 1. The act or process of being altered or changed. 2. An alteration or change, as in n
patient variant (p.Ser550Tyr) recapitulated aspects of the human disease that could be partially treated with a SYK inhibitor or transplantation of bone marrow from wild-type mice. Our studies demonstrate that SYK gain-of-function variants result in a potentially treatable form of inflammatory ...
Similarly, loss and gain of MeCP2 function result in significant effects on neuronal plasticity, dendritic morphol- ogy, processes associated with short- and long-term plasticity, and in excitatory/inhibitory balance in neuro- transmission. It is striking that levels of MeCP2 appear to have a ...
摘要: Gain of function mutations describes mutations that result in new (protein) functions in heterozygous individuals. Huntington's DiseaseLoss of Function MutationMendelian Forms of Human Hypertension... DOI: 10.1007/3-540-29623-9_7112 被引量: 69 年份: 2005 收藏...
as a result of one's efforts; obtain; secure: to gain possession of land; to gain permission to enter. 2. to acquire as an increase or addition: to gain weight; to gain speed. 3. to obtain as a profit or advantage: He didn't stand to gain much by the deal. 4. to win; get...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...
Similar to Arabidopsis thaliana, the wild soybeans (Glycine soja) and many cultivars exhibit indeterminate stem growth specified by the shoot identity gene Dt1, the functional counterpart of Arabidopsis TERMINAL FLOWER1 (TFL1). Mutations in TFL1 and Dt1 both result in the shoot apical meristem (...
The reason is the structure of p53 protein folding dynamic change and intrinsically disordered domain [3, 4]. Studies have shown that most p53 mutations have missense mutation preferentially occurred in the DNA binding domain, as a result of single amino acid change at many different positions [...
This study emphasizes the regulatory function of the 3′-UTR intron. In addition, we also studied the genomic loss and show that “in-frame” deletion of 12 nucleotides led to loss of amino acids IHDF resulting in the generation of a prepro-processing site in BmGlv2. As a result, the...