Define Gain of function. Gain of function synonyms, Gain of function pronunciation, Gain of function translation, English dictionary definition of Gain of function. n. 1. The act or process of being altered or changed. 2. An alteration or change, as in n
Definition Gain of function is the property of some proteins whose alterations determine the acquisition of novel functions mainly opposite to those exerted by the wild-type counterparts. Characteristics The gene product of the tumor suppressor p53 represents a paradigm of a protein whose alterations, ...
Define gain. gain synonyms, gain pronunciation, gain translation, English dictionary definition of gain. v. gained , gain·ing , gains v. tr. 1. To come into possession or use of; acquire: gained a small fortune in real estate; gained vital information a
These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function shown previously to be associated with mutations in this tumour suppressor gene. This is a preview of subscription content, access via your institution Access options Subscription info for Ch...
摘要: A gain-of-function mutation is any mutation of a gene that causes increased function and/or activity of its encoded protein or of a protein that is directly or indirectly regulated by the mutated... DOI: 10.1007/3-540-30683-8_620 被引量: 8 年份: 2001 收藏...
COVID-19 and the gain of function debates: Improving biosafety measures requires a more precise definition of which experiments would raise safety concerns The COVID-19 pandemic has rekindled debates about gain-of-function experiments. This is an opportunity to clearly define safety risks and appropr...
Gain-of-function mutations, also called “activating mutations,” change the gene product such that its effect gets stronger (enhanced activation) or even is superseded by a different and abnormal function. From: Self-Assessment Questions for Clinical Molecular Genetics, 2019 ...
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by definition, tend to be more tolerant of heterozygous damaging mutations. Therefore, we selected a subset of variants that have been observed in a homozygous state at least once in gnomAD, with the expectation that these should be more reflective of truly benign variants (although at the cost...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...