Learn more about the signs, symptoms, and diagnosis of generalized anxiety disorder, who is most at risk to get it, and what treatment and recovery involves.
Using mice with a null mutation of the GABA synthetizing enzyme glutamate decarboxylase 65 (GAD65−/−), we started to compare anxiety-like behavior and avoidance in male vs. female GAD65−/− mice and their wildtype littermates. In an open field, female GAD65−/− mice ...
Clinical Research Unit for Anxiety Disorders, University of New South Wales at St Vincent's Hospital, Sydney, AustraliaElsevier LtdBehaviour Research & TherapyHolt PE, Andrews G (1989) Hyperventilation and anxiety in panic disorder, social phobia, GAD and normal controls. Behav Res Ther 27:453-...
2Yerkes National Primate Research Center, Atlanta, GA, USA; 3Harvard Medical School/McLean Hospital, Boston, MA, USA The study of inflammation in fear- and anxiety-based disorders has gained interest as growing literature indicates that pro- inflammatory markers can directly modulate affective behavio...
“third wave” CBT. These approaches are grounded on the premise that unpleasant thoughts and feelings are a normal part of the human experience, and that trying to control them actually makes them worse. This“third wave”approach focuses instead on accepting the presence of unwanted thoughts ...
Clinical evidence suggests that alterations in normal γ-aminobutyric acid (GABA) transmission might contribute to the pathophysiology of anxiety disorders in humans. For instance, various studies using nuclear imaging techniques have revealed diminished central GABA and GABA receptor levels in patients suff...
Participant responses to items concerning worry tended to be higher on the GAD-7 than analogous questions on the DASS-Anxiety related to panic and this may have contributed to the GAD-7 assigning more above normal threshold scores versus the DASS-Anxiety. When the DASS-Stress scale, which ...
However, whether hypersensitivity of the HPAA to CS also exists in PEE offspring fed a normal diet, whether gender differences exist in the mechanism resulting in HPAA hypersensitivity and whether epigenetic modification is involved in the hypersensitivity of the HPAA are unclear. The hypothalamic ...
Depression is linked to changes in GABAergic inhibitory neurons, especially parvalbumin (PV) interneurons, which are susceptible to redox dysregulation. Olanzapine (Olz) is an atypical antipsychotic whose mode of action remains unclear. We determined the