The clinical demonstration of the major antidepressant action of GABAmimetic agents (Morselli et al., 1980; 1986; Musch, 1986; Weiss et al., 1986) has led to the formulation of a coherent GABA hypothesis of depression. This hypothesis in addition is supported by a large body of evidence ...
综上所述,关于GABA-A受体的现有数据,它们在大脑中的功能,大脑对缺乏GABA活性的反应,以及GABA-A促进药物治疗围产期抑郁症的成功,表明GABA-A受体是抑郁症的重要因素,不仅是情感症状,而且是治疗认知症状的关键靶点,作者总结道。 GABAA receptors as targets for treating affective and cognitive symptoms of depression...
Treatments modulating the neurotransmitter GABA and its main receptors in the brain could help address both the affective and cognitive symptoms associated with depression, such artist Vincent Van Gogh is suspected to have experienced, the authors of a new paper say. Credit: "Sorrowing Old Man (At...
A., “GABAB receptors and depression. Current status,” Adv. Pharmacol., 58, 427–451 (2010). Article CAS PubMed Google Scholar Davis, M., “NMDA receptors and fear extinction: implications for cognitive behavioral therapy,” Dialogues Clin. Neurosci., 13, No. 4, 463–474 (2011). Pub...
WILLIAM C. Mobley Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer...
Transmission of GLU and GABA in the CNS controls the neural excitatory/inhibitory balance to keep the brain in an optimal state for optimal function. Previous studies have shown that humans have two types of GABA receptors: fast-acting ionotropic GABAA receptors (GABAARs) and slow-acting ...
GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and psychological processes. Thus, dysfunction of the GABA system is implicated in the pathophysiology of several neuropsychiatric disorders, including anxiety and depression. However, the role of GABA B receptors in beh...
[5] .ROBERT A, RISSMAN, WILLIAM C. Mobley Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease[J]. Journal of Neurochemistry, 2011, 117: 613–622. [6] .PRAGER E M, BERGSTROM H C, Wynn G H, et al. The basolateral amygdala γ-aminobutyric acider...
Physical signs, such as aches, stomach and digestive problems, and headaches Sadness Depression has been linked to lower levels of GABA in the brain. Some evidence suggests that medications that stimulate GABA receptors can improve the effects of antidepressants if you take them together.6Taking GAB...
It consists of GABA(A) and GABA(B) receptors, with the GABA(A) receptor being a pentameric ion channel permeable to chloride ions, influenced by the binding of GABA and various drugs, while the GABA(B) receptor is a heterodimer that mediates inhibitory effects through potassium activation and...