Verleye, M., Dumas, S., Heulard, I., et al., “Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?” Eur. Neuropsychopharmacol., 21, No. 6, 457–470 (2011...
To assess the role of GABA(A) receptor subunits on USVs, drugs that have preferential actions at different GABA(A)-alpha subunits (L-838417 and QH-ii-066) were tested. Seven-day-old CFW mouse pups were separated from their dam and littermates and placed individually on a 19 degrees C...
3.2. GABAB receptor regulation Studies have shown that GABABRs are associated with a number of behavioral and central nervous system disorders, including depression, anxiety, epilepsy, panic, and sleep disorders [43]. GABABRs consist of two subunits, GABAB1 and GABAB2.Both subunits are composed ...
In both brain regions, D3 receptor activation is believed to reduce the activity of protein kinase A via inhibition of adenylyl cyclase. This ultimately decreases the phosphorylation of GABAA subunits making the receptor complex a substrate for clathrin-mediated endocytosis (Chen et al, 2006). ...
Hippocampal astrocytes modulate anxiety-like behavior Article Open access 07 November 2022 Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents Article Open access 18 October 2021 BNST PKCδ neurons...
It is thus possible that anxiety could be caused by an altered expression or subunit composition of GABA-A receptors.This research project aims to identify differences in the expression of GABA-A receptor subunits in genetic mouse models of high (HAB), normal (NAB), and low (LAB) anxiety ...
It is composed of a 2-kb open reading frame encoding one of the GABA receptor subunits. In all D. melanogaster resistant individuals, the Rdl locus displays a similar mutation at postion 302 in the channel-lining domain sequence, changing an alanine into a serine (A302S). The role of ...
In each of the regions of the basal ganglia that have been studied, GABA(A) receptor subunits are located primarily at symmetrical synapses formed by GABAergic boutons, where they display a several-hundred-fold enrichment over extrasynaptic sites. In contrast, GABA(B) receptors are widely ...
diversity of GABAARs, the native isoforms have to be identified by their localization in the brain and by their pharmacology. In heterologous expression systems, channels require the presence of α, β, and γ subunits in order to mimic the full repertoire of native receptor responses to drugs,...
Real-time PCR analysis indicates that BnST neurons express high levels of GABAA receptor subunits, including a1, a2, g2, and g1 (data not shown), that we have shown form receptors that are sensitive to acute positive allosteric modulation by the AAS (Yang et al, 2002, 2005; Clark et ...